Relationship Between Amyloid-β Positivity and Progression to Mild Cognitive Impairment or Dementia over 8 Years in Cognitively Normal Older Adults

Journal of Alzheimer's Disease : JAD
Christa DangAIBL Research Group

Abstract

Preclinical Alzheimer's disease (AD) is defined by cerebral amyloid-β positivity (Aβ+) in cognitively normal (CN) older adults. To estimate the risk of progression to the symptomatic stages of AD due to PET Aβ+ and the extent that progression was influenced by other demographic, genetic, and clinical characteristics in a large prospective study. Fine-Gray subdistribution modeling was used to examine the risk of progression from CN to MCI/dementia due to Aβ+, APOEɛ4 carriage, and their interaction in the Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging CN cohort (n = 599) over 8 years. 17.7% Aβ+ and 8.1% Aβ-progressed over 8 years (OR: 2.43). Risk of progression for Aβ+ was 65-104% greater than Aβ-. Aβ+ APOEɛ4 carriers were at 348% greater risk than all other participants. Significant risk factors of progression in Aβ+ were age (HR: 1.05), PET SUVR (HR: 2.49) and APOE ɛ4 carriage (HR: 2.63); only age was a significant risk factor in Aβ-(HR: 1.09). Aβ-progressors were not near the threshold for Aβ+. These relationships were not moderated by hypertension, diabetes, obesity, or stroke/TIA. Aβ+ is an important prognostic marker for progression from CN to MCI/dementia in older adults and APOEɛ4 carriage pro...Continue Reading

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Citations

Jan 8, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Christa DangUNKNOWN AIBL Research Group
Oct 3, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Miriam T AshfordRachel L Nosheny
Nov 25, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kathryn V PappUNKNOWN Collaborators from the Harvard Aging Brain Study, the Alzheimer's Disease Neuroimaging Initiative and the Australian Imaging
Sep 5, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Eric McDadeAnn Marie Hake
Mar 23, 2021·Journal of the International Neuropsychological Society : JINS·Ellen GroberSusan M Resnick
Sep 6, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Thibault MuraUNKNOWN GuidAge/DSA study group*

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Clinical Trials Mentioned

NCT02569398
NCT02008357

Software Mentioned

SPSS
R

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