Relationship between angiotensin-converting enzyme insertion/deletion gene polymorphism and systemic lupus erythematosus/lupus nephritis: a systematic review and metaanalysis

The Journal of Rheumatology
Tian-Biao ZhouDan-Dan Peng

Abstract

Results from studies of the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and systemic lupus erythematosus (SLE)/lupus nephritis (LN) are controversial. We performed this metaanalysis to evaluate the relationship between ACE I/D gene polymorphism and SLE/LN and to explore whether the ACE D allele or DD genotype could become a predictive marker for risk of SLE/LN. Association studies were identified from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of May 1, 2011, and eligible investigations were synthesized using a metaanalysis method. Results were expressed with OR for dichotomous data, and 95% CI were calculated. Sixteen investigations were identified for the analysis of association between ACE I/D gene polymorphism and SLE, consisting of 1959 patients with SLE and 2078 controls. In the overall populations, there was a marked association between D allele or DD genotype and SLE susceptibility (D: OR 1.29, 95% CI 1.04-1.58, p = 0.02; DD: OR 1.60, 95% CI 1.17-2.19, p = 0.003), and DD homozygous was associated with LN risk (OR 2.78, 95% CI 1.26-6.11, p = 0.01). In the subgroup analysis, DD genotype associated with SLE ri...Continue Reading

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Citations

Jun 5, 2013·Genomics, Proteomics & Bioinformatics·Yajuan LiQuan-Zhen Li
Nov 10, 2012·Immunopharmacology and Immunotoxicology·Jorge F Topete-ReyesMario Salazar-Páramo
Aug 6, 2014·Journal of Receptor and Signal Transduction Research·Chao OuLe-Qun Li
Aug 27, 2013·Journal of Receptor and Signal Transduction Research·Tian-Biao ZhouZong-Pei Jiang
May 24, 2014·Journal of Receptor and Signal Transduction Research·Tian-Biao ZhouNing Su
Jun 27, 2014·Journal of Receptor and Signal Transduction Research·Tian-Biao ZhouYa-Juan Huang
Apr 1, 2015·Nature Reviews. Nephrology·Chandra Mohan, Chaim Putterman
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Mar 19, 2015·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Chun-Hua YangHong-Yan Li
Mar 5, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Samuel K ShinjoSuely Kn Marie

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