PMID: 11905588Mar 22, 2002Paper

Relationship between anti-neutrophil cytoplasmic antibody determined with conventional binding and the capture assay, and long-term clinical course in vasculitis

Journal of Internal Medicine
K GisslénH Herlitz

Abstract

To evaluate the relationship between anti-neutrophil cytoplasmic antibody (ANCA) measured with two different methods and long-term clinical course in vasculitis. Retrospective determination of ANCA with two different assays for detection of PR3-ANCA, conventional direct binding ELISA and capture ELISA using monoclonal antibodies against PR3. The 245 ANCA determinations were performed from frozen blood samples collected three to four times a year in each patient. Department of Nephrology at a Swedish University Hospital. A total of 10 ANCA-positive patients with vasculitis caused by Wegener's granulomatosis (WG) or microscopic polyarteritis (MPA) and a very long follow-up time (mean 9 years, range 5-15.5 years). The total number of episodes with active vasculitis was 29 and all of them (100%) were detected by the capture technique whilst the conventional technique detected 23 (79%). The mean number of episodes with active disease requiring treatment with steroids and cytotoxic drugs was three per patient (range 1-6). At the time of clinical relapse of the vasculitis disease, the ANCA titre using the capture technique was either increasing or showed a very high value in all cases. The pattern of capture ANCA response could be sub...Continue Reading

References

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Citations

Jun 7, 2012·Clinical Reviews in Allergy & Immunology·Jan Willem Cohen Tervaert, Jan Damoiseaux
Sep 19, 2003·European Journal of Internal Medicine·A RutgersJ W. Tervaert
Jun 24, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anthony D BoothDavid R Jayne
Oct 27, 2004·Nephrology·David Jayne
Nov 7, 2008·Nephrology·Grant LuxtonUNKNOWN Caring for Australians with Renal Impairment (CARI)
Jun 4, 2014·Nature Reviews. Rheumatology·Elena Csernok, Frank Moosig
Dec 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rainer BirckFokko J van der Woude
Dec 18, 2003·Clinical and Experimental Immunology·D SelgaT Hellmark
Oct 1, 2005·Seminars in Arthritis and Rheumatism·Michael SamarkosKevin A Davies
Feb 18, 2016·Arthritis & Rheumatology·Lynn A FussnerUNKNOWN Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group
Mar 17, 2015·Current Opinion in Rheumatology·Lynn A Fussner, Ulrich Specks
Dec 16, 2003·Current Opinion in Rheumatology·Wilhelm H Schmitt, Fokko J van der Woude
Nov 16, 2013·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Yoshihiro Arimura
Nov 23, 2005·La Presse médicale·L F Flores-Suarez

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