PMID: 9163911May 1, 1997Paper

Relationship between antibacterial activity and cell surface binding of lactoferrin in species of genus Micrococcus

FEMS Microbiology Letters
A de LilloJ F Fierro

Abstract

Human lactoferrin was bactericidal in vitro for Micrococcus luteus but not for other Micrococcus species (M. radiophilus, M. roseus and M. varians). A correlation between the binding of lactoferrin to the bacterial surface and the antimicrobial action was observed. Viability assays showed that ferric, but not ferrous, salts prevented binding and consequently M. luteus was not killed. The unsaturated form of lactoferrin showed a greater affinity than that of the iron-saturated molecule for lipomannan, a lipoglycan present on the cell wall of M. luteus, supporting the role for lipomannan as one of the possible binding sites of lactoferrin on M. luteus.

References

Jul 15, 1977·Science·R R ArnoldJ R McGhee
Nov 1, 1992·Journal of Medical Microbiology·A R KishoreA S Naidu
May 1, 1992·Archives of Disease in Childhood·L SánchezJ H Brock
Jan 1, 1990·Medical Microbiology and Immunology·P ViscaP Valenti
Dec 23, 1968·Biochimica Et Biophysica Acta·J D Oram, B Reiter
Sep 1, 1983·Reviews of Infectious Diseases·R A FinkelsteinM A McIntosh
Jun 1, 1994·Infection and Immunity·B J AppelmelkJ H Nuijens

❮ Previous
Next ❯

Citations

Jun 20, 2002·Artificial Organs·Reza ArdehaliGregory L Burns
May 22, 2007·Biochemistry. Biokhimii︠a︡·M N BerlovV N Kokryakov
Jan 18, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Qun WuHong Wei Chu
Feb 28, 2001·FEBS Letters·R FroidevauxD Guillochon
Sep 15, 2004·FEMS Immunology and Medical Microbiology·Mónica Viejo-DíazJosé F Fierro
Jun 20, 2012·Journal of Food Science·M Melissa HayesAnnel K Greene
Nov 1, 2020·Antibiotics·Alexey S AfoshinNatalia V Vasilyeva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.