Relationship between antiphospholipid antibodies and progression of lower extremity arterial occlusive disease after lower extremity bypass operations

Journal of Vascular Surgery
E Y LamG L Moneta

Abstract

Antiphospholipid antibodies (APLs), which consist of anticardiolipin antibodies (ACLs) or lupus anticoagulant (LA), are associated with venous thrombosis, stroke, and cardiac events. Although they are present in many patients with lower extremity atherosclerotic occlusive disease (LEAOD), the relationship between APL and the progression of LEAOD has not been reported. A comparison of progression of LEAOD as determined with direct imaging studies in patients with and without APL forms the basis for this report. APL+ patients (immunoglobulin M [IgM] or IgA or IgG ACL > 3 SD units above control mean or positive LA) who underwent lower extremity bypass grafting between January 1990 and June 1999 (n = 79) were compared with an APL control group (n = 68). Members of the study and control groups were similar with respect to age, procedure, sex, length of follow-up, and multiple atherosclerosis risk factors. Progression of LEAOD was determined by comparing preoperative arteriograms with postoperative imaging studies (arteriograms or duplex scanning). External iliac, common femoral, superficial femoral and popliteal arteries were graded as < 50% stenosis, > or = 50% stenosis, or occluded. Posterior tibial and anterior tibial arteries we...Continue Reading

References

Mar 1, 1991·American Journal of Hematology·Z M SthoegerA Berrebi
Jun 1, 1990·Journal of Vascular Surgery·M C DonaldsonJ A Mannick
Mar 1, 1989·Annals of Neurology·D P BrileyS H Goodnight
Nov 21, 1985·The New England Journal of Medicine·D W BranchE Hershgold
Apr 1, 1995·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L J FligelstoneI F Lane
Aug 1, 1995·American Journal of Surgery·R G CioccaA M Graham
Jul 1, 1993·European Journal of Vascular Surgery·S NiteckiS Torem
Jun 17, 2000·Baillière's Best Practice & Research. Clinical Haematology·S L FieldC N Chesterman

❮ Previous
Next ❯

Citations

Mar 8, 2005·Journal of Thrombosis and Haemostasis : JTH·R MarcucciR Abbate
Oct 28, 2004·Thrombosis Research·Panayiotis G Vlachoyiannopoulos, Michael Samarkos
Jul 23, 2008·Journal of Vascular Surgery·Lannery S LauvaoJohn D Hughes
Jan 27, 2004·Journal of Vascular Surgery·Everett Y LamGregory L Moneta
Mar 16, 2005·Journal of Vascular Surgery·Francesco SofiDomenico Prisco
Oct 11, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M SartoriG Palareti
Jan 18, 2015·Annals of Vascular Surgery·Sotirios GiannakakisChrisostomos Maltezos
Jul 6, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S VigA Halliday
Jul 20, 2004·Angiology·José Maria Pereira de GodoyDorotéia R S Souza
Apr 20, 2004·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·M Akif OztürkHakan Göker
Aug 16, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·David Feinbloom, Kenneth A Bauer
Oct 16, 2014·Journal of the American Heart Association·Victoria UlrichChieko Mineo
Apr 25, 2015·Circulation Research·Michael H Criqui, Victor Aboyans
Apr 12, 2006·The British Journal of Surgery·S VigA Halliday
Jan 1, 2008·Expert Review of Clinical Immunology·Paul R J AmesAnnamaria Margarita
Jun 12, 2020·Hemodialysis International·Paul R J AmesFabrizio Gentile
Oct 17, 2020·Seminars in Arthritis and Rheumatism·Mira MerashliPaul Rj Ames
Nov 8, 2002·Archives of Pathology & Laboratory Medicine·Elizabeth M Van CottMartin H Prins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.