PMID: 75248Dec 1, 1977Paper

Relationship between arteriosclerosis and cerebral atrophy in Parkinson's disease

Journal of Neurology
E SchneiderP Jacobi

Abstract

Computed tomographic examinations of parkinsonian patients revealed a high incidence of cerebral atrophy, in most cases a combination of cortical atrophy and ventricular enlargement. The present study considered the relationship between cerebral atrophy and physical signs indicating or promoting arteriosclerosis such as overweight, electrocardiographic changes, hypertension, calcification of the internal carotid artery and aorta as well as elongation of the aorta. The study is based on 173 treated and untreated parkinsonian patients (89 men, 84 women) aged from 37--84 years (mean 64.6), on whom CT was performed about 5.4 years after the onset of the first symptoms of the illness. The results demonstrate an increase of pathological CT findings as well as of calcification in the carotid siphon with advanced age. No correlation was found between the other items and increasing age. Further analysis of the relationship between cerebral atrophy and signs of arteriosclerosis revealed only a statistically relevant correlation with calcification of the carotid siphon, especially with calcification of the media. Since pathological CT findings and calcification of the internal carotid artery are both related to advanced age, whereas all t...Continue Reading

References

Apr 1, 1963·The British Journal of Radiology·M COLE, H DAVIES
Jun 1, 1964·Journal of Neurology, Neurosurgery, and Psychiatry·M J EADIE, J M SUTHERLAND

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Citations

Jul 1, 1979·Journal of the Neurological Sciences·E SchneiderH Hacker
Jan 1, 1980·Clinical Neurology and Neurosurgery·J de ReuckH vander Ecken
Aug 1, 1983·Brain Research Bulletin·J A Byer, J D Dexter
Jul 4, 1979·Archiv für Psychiatrie und Nervenkrankheiten·E SchneiderR Brinkmann
Dec 1, 1991·Journal of Autism and Developmental Disorders·R Van Acker

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