Relationship between attentional performance and corpus callosum morphometry in patients with Alzheimer's disease

Neuropsychologia
Agnès A DorionMichel Duyme

Abstract

There has been considerable interest in cognitive deficits associated with Alzheimer's disease (AD) and relationships between these impairments and specific cortical atrophies. Two previous studies [Neuropsychologia 28 (1990) 1197; Dementia 3 (1992) 350] have found that AD patients exhibit significant impairments in the attentional ID/ED set-shifting tasks of the CANTAB battery which involved attentional shifting abilities. But, at present, no study has examined the neural bases of these abilities in AD patients. In the present study, the relationship between performances on this attentional test and morphometry of the anterior and posterior corpus callosum is examined in AD patients in the mild to moderate stages of the disease (n=30, mean age=74.1+/-4.9 years, mean MMSE score=23.9+/-2.6). A control group is constituted (n=20, mean age=73.15+/-5.5 years) for comparison of cerebral measurements. The stepwise multiple regression analysis indicates that the relative contribution for the total callosal and the anterior CC areas of the simple discrimination subtest is significantly positive whereas for the posterior callosal areas the relative contribution of the more complex subtest is significantly positive. AD patients from the ...Continue Reading

References

Sep 1, 1979·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·L Ellenberg, R W Sperry
Jun 1, 1976·Brain : a Journal of Neurology·S J Dimond
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jul 1, 1989·The International Journal of Neuroscience·S WeisM Kimbacher
Feb 12, 1986·Brain Research·K S Rockland, D N Pandya
Jan 1, 1985·Brain and Cognition·B A OberD C Delis
Nov 1, 1985·Journal of Neuropathology and Experimental Neurology·M C de LacosteE D Ross
Jan 10, 1982·The Journal of Comparative Neurology·D N Pandya, B Seltzer
Sep 1, 1984·Brain and Language·N D Cook
Jan 1, 1984·Experimental Brain Research·H Barbas, D N Pandya
Jan 1, 1983·Experimental Brain Research·B Seltzer, D N Pandya
Jul 22, 1983·Science·H WeingartnerP R Martin
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Oct 1, 1980·Acta Psychologica·Y Guiard
May 1, 1995·Neurobiology of Aging·H Braak, E Braak
Jun 1, 1995·Neuropsychologia·M Y YazganJ F Leckman
Jan 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·G BinettiM Trabucchi
Jul 1, 1996·Neurotoxicology and Teratology·P J Fray, T W Robbins
Oct 1, 1996·Journal of the Neurological Sciences·F FazekasG Fazekas
Aug 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·E MoriA Yamadori
Jul 3, 1998·Cerebral Cortex·D N KennedyV S Caviness
Jun 12, 1999·Dementia and Geriatric Cognitive Disorders·M GolebiowskiA Pfeffer
Apr 19, 2000·Journal of Cognitive Neuroscience·R Cabeza, L Nyberg

❮ Previous
Next ❯

Citations

Mar 17, 2004·Brain Research. Cognitive Brain Research·Simona SpinelliChristopher R Pryce
Jun 14, 2003·Neuropsychology·Elizabeth A KensingerSuzanne Corkin
Sep 19, 2006·The Clinical Neuropsychologist·Grant L Iverson
Mar 3, 2012·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Russell M BauerRichard I Naugle
Sep 30, 2005·Dementia and Geriatric Cognitive Disorders·Katie WiltshireRichard Camicioli
Feb 10, 2011·PloS One·A Jennifer Morton, Laura Avanzo
Mar 13, 2014·Brain and Cognition·Anna OhElizabeth W Pang
Oct 31, 2008·Journal of Clinical and Experimental Neuropsychology·Grant L IversonC Thomas Gualtieri
Oct 24, 2007·Brain and Cognition·Diego Fernandez-Duque, Sandra E Black
Oct 18, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Leodante da CostaElizabeth W Pang
Nov 8, 2005·Neurobiology of Aging·Paul J WangAlexander C Mamourian
Dec 20, 2011·Learning and Individual Differences·Jessica F CantlonKevin A Pelphrey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.