Relationship between background parenchymal enhancement on breast MRI and pathological tumor response in breast cancer patients receiving neoadjuvant chemotherapy

The British Journal of Radiology
Seon Jeong OhHak Hee Kim

Abstract

To evaluate the impact of background parenchymal enhancement (BPE) on breast MRI and pathological tumor responses to neoadjuvant chemotherapy (NAC) in breast cancer patients. A panel of 372 MRI from 186 pathologically confirmed breast cancer patients who underwent breast MRI before and after NAC were selected. BPE was classified into four categories before and after NAC. The association between BPE and the pathological tumor response to NAC, recurrence-free survival (RFS) and molecular subtypes were analyzed. We also evaluated the associations between the baseline BPE before NAC and menopausal status or mammographic parenchymal density. Baseline BPE did not differ significantly according to the pathological tumor response to NAC (p = 0.2019). However, changes in BPE after NAC were significantly greater in the pathological complete remission (pCR) group than in the non-pCR group (p = 0.0008). There was no statistically significant association between BPE and RFS or molecular subtypes. The baseline BPE of pre-menopausal females (2.77 ± 0.86) were greater than those of post-menopausal females (2.05 ± 0.69), with statistical significance (p < 0.0001). Baseline BPE showed no significant difference according to mammographic parenchym...Continue Reading

References

Nov 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A van der HageL Duchateau
Jul 31, 2002·Gan to kagaku ryoho. Cancer & chemotherapy·Hideo InajiHiroki Koyama
Aug 28, 2002·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Tadashi IkedaMasaki Kitajima
Oct 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry D BearUNKNOWN National Surgical Adjuvant Breast and Bowel Project Protocol B-27
Dec 6, 2003·The Oncologist·Sharon H Giordano
Feb 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R GralowEric P Winer
May 22, 2008·AJR. American Journal of Roentgenology·Jona HattangadiNola Hylton
Feb 15, 2011·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·P A BaltzerW A Kaiser
Apr 16, 2011·Radiology·Valencia KingElizabeth A Morris
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne F Schott, Daniel F Hayes
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gunter von MinckwitzSibylle Loibl

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Citations

Apr 21, 2019·Journal of Magnetic Resonance Imaging : JMRI·Geraldine J LiaoHabib Rahbar
Apr 1, 2020·Journal of Magnetic Resonance Imaging : JMRI·Beatriu ReigLinda Moy

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