Relationship between BDNF- and trk-expressing neurones in rat dorsal root ganglion: an analysis by in situ hybridization

Neuroreport
H KashibaE Senba

Abstract

Brain-derived neurotrophic factor (BDNF) is synthesized in sensory neurones and suggested to operate on these same neurones by an autocrine mechanism, but it is unclear whether these neurones express the functional receptor (TrkB) for BDNF. We therefore examined the co-localization of BDNF and neurotrophin receptor mRNAs in adult rat dorsal root ganglion (DRG) neurones by in situ hybridization histochemistry. BDNF mRNA signals were detected in about 40-50% of DRG neurones (L4-5). Almost all the trkA mRNA-expressing neurones (95%) were positive for BDNF mRNA, while no trkB mRNA- and few trkC mRNA-expressing neurones displayed BDNF mRNA signals. These findings suggest that BDNF is mainly synthesized in the sensory neurones that are responsive to nerve growth factor but not to BDNF or neurotrophin-3. It is unlikely that BDNF is involved in an autocrine loop in sensory ganglia.

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S O MeakinE M Shooter
Feb 18, 1991·Physical Review Letters·D D SarmaW Gudat

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Citations

Oct 31, 2002·The European Journal of Neuroscience·L A KarchewskiV M K Verge
May 5, 1999·Journal of Anatomy·G Terenghi
Dec 9, 2014·Frontiers in Biology·Li-Ya Qiao
Feb 25, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Budd A Tucker, Karen M Mearow

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