Relationship between BMI and all-cause mortality in Japan: NIPPON DATA80

Obesity
Atsushi HozawaNIPPON DATA80 Study Group

Abstract

As body composition in Asian populations is largely different from Western populations, a healthy BMI could also differ between the two populations. Thus, further study is needed to determine whether a healthy BMI in Asians should be lower than Western populations, as recommended by the World Health Organization (WHO). We investigated the relationship between BMI and mortality in a sample of 8,924 Japanese men and women without stroke or heart disease. During 19 years of follow-up, 1,718 deaths were observed. We found a U-shaped relationship between BMI and fatal events. Risk of total mortality was highest in participants with BMI <18.5 kg/m(2) and lowest in participants with BMI 23.0-24.9 kg/m(2). These findings persisted even after excluding the first 5 years of follow-up with a focus on healthy participants who never smoked, were aged <70 years, and had total cholesterol (TC) levels >or=4.1 mmol/l (N=3712). For both the full sample and healthy participants, all-cause mortality risk did not differ between BMI ranges 21.0-22.9 and 23.0-24.9 kg/m(2). Our findings do not support the recent WHO implications that BMIs <23.0 kg/m(2) is healthy for Asians. Therefore, further studies are needed to identify an optimal BMI range for Asia.

References

Oct 8, 1999·The New England Journal of Medicine·E E CalleC W Heath
Dec 10, 1999·American Journal of Epidemiology·P N SinghG E Fraser
Jul 10, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J A Greenberg
Jun 22, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S TsuganeY Tsubono
May 2, 2003·Nutrition Reviews·June Stevens, Eric M Nowicki
Apr 24, 2004·International Journal of Epidemiology·C Ni MhurchuUNKNOWN Asia Pacific Cohort Studies Collaboration
May 18, 2004·Journal of Epidemiology·Shinichi KuriyamaShigeru Hisamichi
Nov 3, 2004·Annals of Epidemiology·Umed A AjaniJoann E Manson
Dec 25, 2004·Diabetes Care·UNKNOWN American Diabetes Association
May 28, 2005·Stroke; a Journal of Cerebral Circulation·Renzhe CuiUNKNOWN JACC Study Group
Jun 3, 2005·Journal of Epidemiology·Rumiko HayashiShosuke Suzuki
Feb 1, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T KadowakiH Ueshima
Aug 5, 2006·Cerebrovascular Diseases·Izumi OkiUNKNOWN Nippon Data80 Research Group
Aug 24, 2006·The New England Journal of Medicine·Kenneth F AdamsMichael F Leitzmann
Aug 24, 2006·The New England Journal of Medicine·Sun Ha JeeJonathan M Samet
Dec 22, 2006·The New England Journal of Medicine·Sang Woo Oh

❮ Previous
Next ❯

Citations

Nov 3, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T MatsuoT Muto
May 29, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Shin-ichiro Imai
Dec 30, 2011·BMC Medical Research Methodology·Edwin S WongSean D Sullivan
Mar 23, 2011·Journal of Epidemiology·Yuji NishiwakiUNKNOWN Kurabuchi Study Group
Nov 10, 2010·American Journal of Epidemiology·Katherine M FlegalRichard S Cooper
May 29, 2012·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Toshio ShimizuTetsuo Komori
Mar 4, 2009·Preventive Medicine·Akiko TamakoshiUNKNOWN JACC Study Group
Mar 28, 2012·Clinical Transplantation·Ichiro NakajimaShohei Fuchinoue
Jun 10, 2015·Economics and Human Biology·Shiko Maruyama, Sayaka Nakamura
Jan 29, 2011·Journal of Dental Research·I MoritaW Sabbah
Mar 7, 2014·Journal of Atherosclerosis and Thrombosis·Yuri KawabeHirotsugu Ueshima
May 19, 2017·Gerontology & Geriatric Medicine·Tomoko ShimodaSadako Yoshimura
Oct 11, 2020·The American Journal of Clinical Nutrition·Hannah OhMin-Jeong Shin
Jul 7, 2021·Korean Circulation Journal·Ahmed ArafaHiroyasu Iso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved