Relationship between body weight and postmenstrual age in a Korean pediatric population

Translational and Clinical Pharmacology
Jinju GukKyungsoo Park

Abstract

Weight is a covariate representative of body size and is known to influence drug disposition. Recently, with increased use of allometric scaling, this variable has become more significant in accounting for variability in pharmacokinetic parameters. In adults, weight can be considered as a time invariant covariate because physical development is complete. As a result, when weight is missing in data, the typical or median value (say, 70 kg) could be imputed. On the contrary, weight continuously changes with age in the pediatric population. In this case, it is more appropriate to consider different median weight for each age group. We constructed a prediction model for weight using postmenstrual age (PMA) with the data consisting of 83,014 Korean pediatric patients. Weight, PMA, and gender information were collected from electronic medical records. Sigmoid models multiplied by exponential or logistic function were tested for basic model structure. Covariate effects on model parameters were then investigated using selection criteria of p < 0.001. All analyses were performed using NONMEM 7.3.0 and R3.2.0. The sigmoid model multiplied by logistic function best described the data and there was a significant difference between boys and...Continue Reading

References

Oct 11, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Malin M RhodinNick H G Holford
Feb 16, 2011·Paediatric Anaesthesia·Anita L Sumpter, Nick H G Holford
May 8, 2013·Journal of Pharmaceutical Sciences·Nick HolfordBrian Anderson

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Citations

Jan 16, 2019·Antimicrobial Agents and Chemotherapy·Si-Chan LiYang Wang

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Methods Mentioned

BETA
PMA
PMAs

Software Mentioned

NONMEM

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