Relationship Between C-Reactive Protein to Albumin Ratio and Thrombus Burden in Patients With Acute Coronary Syndrome

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Hakan DumanNadir Emlek

Abstract

Increased coronary thrombus burden is known to be a strong predictor of adverse cardiovascular (CV) outcomes. C-reactive protein to albumin ratio (CAR) can be used as a surrogate marker of pro-inflammation which is closely related to prothrombotic state. We aimed to evaluate the association between CAR and coronary thrombus burden in patients who presented with acute coronary syndrome (ACS). Patients who presented with ACS and treated with primary percutaneous coronary intervention were included in the study. Patients were divided into 2 groups as high thrombus burden and low thrombus burden. The study population included 347 patients with non-ST-segment elevation myocardial infarction (169 [48.7%]) and ST-segment elevation myocardial infarction (178 [51.3%]). The CAR was significantly higher in patients with higher thrombus burden (24.4 [1.2-30.2] vs 31.9 [2.2-31.3], P < .001). Independent predictors for increased thrombus burden were higher CRP level (odds ratio [OR]: 0.047; 95% confidence interval [CI]: 0.004-0.486; P = .010), lower serum albumin level (OR: 0.057; 95% CI: 0.033-0.990; P = .049), higher CAR (OR: 1.13; 95% CI: 1.03-1.23; P = .008), higher neutrophil-lymphocyte ratio (OR: 1.18; 95% CI: 1.05-1.31; P = .004), and...Continue Reading

References

Nov 17, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·René P AndriéDirk Skowasch
Mar 30, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ibrahim Halil TanbogaMahmut Acikel
Jun 4, 2013·Journal of the American College of Cardiology·Omair YousufMatthew J Budoff
Jan 30, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Hong-Mei LaiBang-Dang Chen
Aug 19, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Arif ArısoyÇağrı Zorlu

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Citations

Dec 13, 2019·Canadian Journal of Gastroenterology & Hepatology·Wisam SbeitTawfik Khoury
Dec 18, 2020·Arquivos brasileiros de cardiologia·Alper SercelikSerdar Turkmen
Jul 22, 2021·Journal of Inflammation Research·Tiewei LiMinglu Qi
Aug 24, 2021·Psychophysiology·Charlotte M RoddickFrances S Chen

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

MedCalc
SPSS
CAR

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