Relationship between C-reactive protein concentrations during glucocorticoid therapy and recurrent atrial fibrillation

European Heart Journal
John Dernellis, Maria Panaretou

Abstract

Little direct information is available on the effect of C-Reactive Protein (CRP) lowering on the reduction of recurrent atrial fibrillation (AF). We compared low-dose glucocorticoid therapy (16 mg methylprednisolone for 4 weeks tapered to 4 mg for 4 months) and placebo in 104 patients who had experienced persistent AF with a median concentration of CRP 1.14 mg/dL (min=0.01, max=2.58). Methylprednisolone reduced recurrent AF (primary end-point) from 50% in the placebo group to 9.6% in the glucocorticoid group and permanent AF (expanded end-point) from 29% in the placebo group to 2% in the glucocorticoid group. Survival distributions for methylprednisolone were significantly different (for both primary and expanded end-point, P < 0.001). In multivariate Cox analysis, average CRP concentrations during follow-up were significant predictors of the primary end-point, with a relative risk 6.72 (P = 0.006) and the expanded end-point, with a relative risk of 11.67 (P = 0.0006). CRP concentration is a risk factor for recurrent and permanent AF. Methylprednisolone successfully prevents recurrent and permanent AF.

Citations

Jul 5, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Joachim R EhrlichStefan H Hohnloser
Sep 24, 2005·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Akiko Shiroshita-TakeshitaStanley Nattel
Mar 5, 2008·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Maya GuglinAnne B Curtis
Jun 5, 2008·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·A John Camm, Irina Savelieva
Jun 7, 2008·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Matthias HammwöhnerAndreas Goette
Mar 29, 2006·Nature Clinical Practice. Cardiovascular Medicine·Samuel Lévy
Dec 21, 2007·Nature Clinical Practice. Cardiovascular Medicine·Irina Savelieva, John Camm
Mar 5, 2008·Antioxidants & Redox Signaling·Timothy WatsonGregory Y H Lip
Feb 7, 2013·European Heart Journal·Ziad HijaziLars Wallentin
Sep 14, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ying LuanYe Tian
Apr 26, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Irene SavelievaA John Camm
Jul 28, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Paulus KirchhofA John Camm
Jan 13, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Marcelle D SmitIsabelle C Van Gelder
Nov 27, 2007·Critical Care : the Official Journal of the Critical Care Forum·Mengalvio E SleeswijkJan G Zijlstra
Dec 17, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi YamashitaTadanori Aizawa
Nov 15, 2011·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Tetsufumi FurukawaTetsuo Sasano
Jul 11, 2009·Vascular Health and Risk Management·Hadi Ar HadiSamer Ellahham
May 16, 2009·Drugs·Joachim R Ehrlich, Stanley Nattel
Jun 9, 2010·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Concepción MoroRoberto Matía
Aug 2, 2011·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·James A HodgkinsonF D Richard Hobbs
Dec 18, 2009·Future Cardiology·Khaja S MohammedSimone Musco
Dec 3, 2014·Heart & Lung : the Journal of Critical Care·Salah S Al-Zaiti
Dec 30, 2014·Saudi Journal of Anaesthesia·Geetanjali ChilkotiPriyanka Khurana
Dec 3, 2014·Cardiology Clinics·Muhammad Rizwan SardarPeter R Kowey
Feb 25, 2010·Nature Reviews. Cardiology·Michiel Rienstra, Isabelle C Van Gelder
Aug 30, 2008·QJM : Monthly Journal of the Association of Physicians·J Sánchez-QuiñonesG Y H Lip
Dec 2, 2006·Nature Reviews. Drug Discovery·Stanley Nattel, Leif Carlsson
Feb 28, 2008·Journal of Hypertension·Roland E SchmiederUNKNOWN VALUE Trial Group
Jul 3, 2008·Journal of Cardiovascular Pharmacology·Brett Burstein, Stanley Nattel
Sep 5, 2006·Der Internist·M G Hennersdorf, B E Strauer
Apr 13, 2005·Medical Hypotheses·Tong Liu, Guangping Li
Aug 12, 2005·Current Opinion in Cardiology·Marino Leonardi, Joe Bissett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.