PMID: 9442454Jan 27, 1998Paper

Relationship between caffeine-induced ocular hypertension and ultrastructure changes of non-pigmented ciliary epithelial cells in rats

The Journal of Toxicological Sciences
K KurataM Tokuriki

Abstract

The purpose of this study was to morphologically assess a possible mechanism for caffeine-induced ocular hypertension. Taking into consideration the relationship between the secretion of aqueous humor and the ultrastructure of the ciliary body, the time course of the morphological features in the ciliary epithelium when caffeine was administered intravenously to male Wistar rats was investigated by electron-microscopy. These morphological findings were also compared with the changes in the intraocular pressure (IOP). A significant increase in IOP was noted 15 min and 1 hr after a single dosing of caffeine alone. This change disappeared in all animals within 2 hr after dosing. The IOP in the animals receiving caffeine and the beta-blocker befunolol, which lowers the IOP by inhibiting aqueous humor secretion, decreased significantly from 15 min after dosing, and this change persisted 2 hr after dosing. In electron-microscopy 15 min and/or 1 hr after dosing with caffeine, a slight dilatation in the lateral intercellular spaces near the basement membrane of the non-pigmented ciliary epithelium was observed and the interdigitations between the non-pigmented epithelial cells were intact. Reversal of these changes was observed 2 hr af...Continue Reading

Citations

Aug 14, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mao LiXinghuai Sun
Feb 12, 2008·Investigative Ophthalmology & Visual Science·Jae Hee KangLouis R Pasquale
Aug 3, 2010·Folia Histochemica Et Cytobiologica·Monika Kujawa-HadryśHieronim Bartel
Nov 13, 2010·Folia Histochemica Et Cytobiologica·Kujawa-Hadryś MonikaBartel Hieronim
Dec 7, 2013·Clinical & Experimental Ophthalmology·Tuan TranDan Nguyen
Feb 10, 2018·Ophthalmology and Therapy·Adi M Al Owaifeer, Abdulaziz A Al Taisan
Dec 16, 2017·The British Journal of Ophthalmology·Connie M WuAnne L Coleman
Nov 9, 2005·Journal of Glaucoma·Sujatha ChandrasekaranPaul Mitchell
Dec 12, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Beatríz RedondoRaimundo Jiménez
Jul 14, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Raimundo JiménezJesús Vera
Jul 23, 1998·The Journal of Veterinary Medical Science·K KurataM Tokuriki

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