Relationship between calcium absorption and plasma dehydroepiandrosterone sulphate (DHEAS) in healthy males

Clinical Endocrinology
R Y T ChenM Horowitz

Abstract

Impaired gut sensitivity to 1,25-dihydroxyvitamin D (1,25(OH)(2)D), leading to reduced intestinal calcium absorption, has been reported in older men and women. While this phenomenon in postmenopausal women has been attributed to oestrogen deficiency, it is unclear whether the same observation in older men correlates with the age-related decline in androgen concentrations. To examine the relationship between androgens and intestinal calcium absorption in older men. Cross-sectional study on 55 healthy male volunteers, divided into younger (n = 27) and older (n = 28) groups separated according to the median age of 59 years. Calcium absorption, total and free (calculated) testosterone, dehydroepiandrosterone sulphate (DHEAS), SHBG, and 1,25(OH)(2)D, among others, were measured. Calcium absorption, free testosterone and DHEAS, but not 1,25(OH)(2)D, declined significantly with age. After adjusting for age and body mass index, stepwise regression showed that 1,25(OH)(2)D and serum albumin were the only significant determinants of calcium absorption in younger men, while the sole determinant in older men was DHEAS, not testosterone. Residual deviations from the regression of calcium absorption on 1,25(OH)(2)D, reflecting the efficiency...Continue Reading

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Citations

Nov 19, 2013·The Journal of Sexual Medicine·Giuseppe BellastellaKatherine Esposito
Jul 22, 2014·Andrology·E LerchbaumB Obermayer-Pietsch
May 26, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Kok-Yong ChinWan Zurinah Wan Ngah
Oct 4, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Ida Marie BoisenMartin Blomberg Jensen
Jan 15, 2014·Nature Reviews. Endocrinology·Martin Blomberg Jensen
May 29, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Martin Blomberg Jensen
Jun 14, 2019·The World Journal of Men's Health·Gianmartin CitoAlessandro Natali
Jul 2, 2017·Reviews in Endocrine & Metabolic Disorders·Cristina de AngelisRosario Pivonello
Sep 25, 2017·The Journal of Clinical Endocrinology and Metabolism·Elisabeth LerchbaumBarbara Obermayer-Pietsch

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