PMID: 8614289Jan 1, 1996Paper

Relationship between cAMP induced inhibition of human meningioma cell proliferation and autocrine secretion of interleukin-6

Life Sciences
A HüttnerE F Adams

Abstract

Previous studies have suggested that activation of the adenylyl cyclase - cAMP system in meningiomas results in decreased mitosis. We have used meningioma cell culture to further investigate this phenomenon and to examine the potential role played by interleukin-6 (IL6). Incubation of cultured meningioma cells for 4-6 days with cholera toxin and theophylline, both of which increase intracellular cAMP levels, markedly stimulated IL6 secretion and inhibited cell growth rate. Similar effects were observed with 8-bromo-cAMP. In contrast, a neutralising polyclonal antibody against IL6 significantly stimulated meningioma proliferation and reduced the inhibitory effects of 8-bromo-cAMP. These results support the concept that IL6 acts as an autocrine / paracrine inhibitory factor for meningioma proliferation, and that the inhibition exerted by elevated intracellular cAMP levels may be at least partially mediated via increased secretion of the cytokine.

References

Jun 25, 1992·Biochemical and Biophysical Research Communications·J IshizukaJ C Thompson
Jun 1, 1988·The Journal of Clinical Endocrinology and Metabolism·P RogerJ E Dumont
Jan 1, 1994·Acta neurochirurgica·T Todo, R Fahlbusch

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Citations

Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T SakamotoA J Demetris
Feb 24, 2001·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·B HuangD Xue
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Noriatsu KannoGianfranco Alpini
Jan 1, 2011·Genetics Research International·Kwanghyuk LeeSuzanne M Leal
Feb 14, 2002·Experimental Cell Research·Tanya J ShawBarbara C Vanderhyden
Nov 2, 2019·Cancers·Antonio CarettaCarla Mucignat-Caretta

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