Relationship between cardiovascular diseases and circulating cell-free nucleic acids in human plasma

Biomarkers in Medicine
Orsolya BiróBálint Nagy

Abstract

Cardiovascular diseases (CVDs) are the main cause of human morbidity and mortality worldwide. Early diagnosis could improve the efficiency of treatments. New biomarkers are needed for the identification of high-risk populations in order to make accurate diagnosis and therapy monitoring. Circulating cell-free nucleic acids (cf-NAs) offer a promising new noninvasive tool. These have a role in the regulation of normal physiological functions and in the development of pathological alterations. There is extended research on the clinical application and utilization of cell-free genomic DNA, mtDNA, mRNA, miRNA and long noncoding RNA in CVDs. These molecules could serve as components of new generation therapeutics. Our review focuses on the role of cf-NAs in the pathogenesis of CVDs and we are discussing also possible diagnostic applications and therapeutic implications.

References

Nov 6, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M StrounP Anker
Jun 18, 2004·European Journal of Clinical Investigation·M DiamantR Nieuwland
Jul 17, 2004·Current Opinion in Hematology·Olivier MorelJean-Marie Freyssinet
Jul 30, 2005·Mitochondrion·Nicolai Balle LarsenLene Juel Rasmussen
Sep 27, 2007·Critical Care : the Official Journal of the Critical Care Forum·Marcela Helena GambimMariano Janiszewski
Apr 17, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Zhiguo WangBaofeng Yang
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Aug 13, 2008·Developmental Cell·Shusheng WangEric N Olson
Feb 28, 2009·Circulation Research·Yajaira Suárez, William C Sessa
Aug 22, 2009·Clinical Chemistry·Xu JiNaoharu Iwai
Nov 10, 2009·Biochemical and Biophysical Research Communications·Jing AiBaofeng Yang
Feb 27, 2010·Circulation Research·Anke J TijsenYigal M Pinto
Mar 12, 2010·Clinical Science·Yunhui ChengChunxiang Zhang
Jun 11, 2010·European Heart Journal·Yuri D'AlessandraMaurizio C Capogrossi
Jul 6, 2010·Journal of Proteomics·Suresh MathivananRichard J Simpson
Jul 7, 2010·Molecular Cell·Yujing ZhangChen-Yu Zhang
Dec 7, 2010·Life Sciences·Terry S EltonDmitry Terentyev
Dec 15, 2010·Critical Reviews in Oncology/hematology·Glen ReidNico van Zandwijk
Dec 15, 2010·Science Translational Medicine·Y M Dennis LoRossa W K Chiu
Dec 16, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasue FukushimaNaoharu Iwai
Dec 21, 2010·European Heart Journal·S AgewallH Katus
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason D ArroyoMuneesh Tewari
Apr 14, 2011·Clinical Chemistry·Jennifer S McDonaldAlicia Algeciras-Schimnich
May 6, 2011·International Journal of Cancer. Journal International Du Cancer·Niels H H HeegaardCurtis C Harris
Jun 7, 2011·Circulation. Cardiovascular Genetics·Yasuhide KuwabaraTakeshi Kimura
Jun 8, 2011·Nature Reviews. Clinical Oncology·Maria Angelica CortezGeorge A Calin
Jun 10, 2011·Journal of Translational Medicine·Sascha KellerPeter Altevogt
Aug 3, 2011·Journal of Molecular and Cellular Cardiology·Christian WideraThomas Thum
Aug 17, 2011·Seminars in Immunopathology·Victor W M van Hinsbergh
Nov 2, 2011·Circulation·David D McManus, Victor Ambros
Nov 22, 2011·Vascular Health and Risk Management·Asli Tanindi, Mustafa Cemri
Jan 19, 2012·Clinical Chemistry·Yvan DevauxDaniel R Wagner
Feb 15, 2012·International Journal of Cardiology·Fabiola OlivieriAntonio Domenico Procopio
Mar 20, 2012·The Journal of Clinical Investigation·Arin B AuroraEric N Olson
Apr 19, 2012·Nature Reviews. Genetics·Colin C PritchardMuneesh Tewari
Jan 29, 2013·Cell·Carla A KlattenhoffLaurie A Boyer
Feb 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Z A MalikA A Knowlton
Mar 7, 2013·Genetics·Johnny T Y KungJeannie T Lee

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Citations

Feb 23, 2019·Clinical Chemistry·Romain MeddebAlain R Thierry
Jul 31, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hannah S RosaAfshan N Malik
Oct 18, 2018·International Journal of Legal Medicine·Katrin BrodbeckSteffen Peldschus

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Methods Mentioned

BETA
biopsy
lavage
ELISA
biopsies

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