Relationship between CD4 count and CD4% in HIV-infected people

International Journal of Epidemiology
L M YuT Marshall

Abstract

To describe the relationship between absolute CD4 count and CD4%, and the influence on this of gender, risk group, age, a diagnosis of AIDS, use of zidovudine (ZDV) therapy and PCP prophylaxis. 9203 paired serial measurements of CD4 count and CD4% on 1017 initially AIDS-free and ZDV-naive HIV positive patients from a London-based cohort were available for analysis. Multi-level regression procedures were used on log-transformed data to relate values of CD4 count to a given level of CD4%. We estimated the effect of selected covariates on this relationship from the exponent of the covariate coefficient. A strong linear relationship was found between log CD4 and log CD4%, CD4 = e 1.78(CD4%)1.26 or 5.93 (CD4%)1.26 (excluding covariates). Based on this model, a CD4% of 5%, 15%, and 30% corresponded to an estimated CD4 count (95% confidence interval [CI]) of 45 cells/mm3 (17-117 cells/mm3), 182 cells/mm3 (64-499 cells/mm3) and 438 cells/mm3 (132-1395 cells/mm3), respectively. However, after adjustment for selected covariates, the predicted CD4 count for a given CD4% was found to be lower among heterosexuals and injecting drug users as compared with homosexual men by 30% and 17% respectively; following an AIDS diagnosis by 21%; and aft...Continue Reading

Citations

Aug 23, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frederick L AlticeGerald H Friedland
Oct 2, 2008·HIV Medicine·B G GazzardUNKNOWN BHIVA Treatment Guidelines Writing Group
Mar 31, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark W HullUNKNOWN Canadian Co-infection Cohort Investigators
Jan 25, 2008·HIV Clinical Trials·J DuvignacR Thiébaut
Aug 3, 2018·Science Translational Medicine·Udo BaronSven Olek
Aug 3, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marília Dalva TurchiAdauto Castelo
Dec 8, 2009·Chemical Reviews·Martin A M GijsUlrike Lehmann
Dec 6, 2008·Analytical Chemistry·Pulak NathAaron J Fleischman

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