Relationship between CD4+ T-cell counts/HIV-1 RNA plasma viral load and AIDS-defining events among persons followed in the ACTG longitudinal linked randomized trials study.

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Marlene SmurzynskiSusan L Koletar

Abstract

AIDS-defining events (ADEs) decreased in the era of highly active antiretroviral therapy but still lead to hospitalizations and deaths. Understanding factors related to ADEs is important to mitigate events. We examined the relationship between demographics, behaviors, comorbidities, laboratory, clinical measurements, and ADEs diagnosed among subjects randomized to antiretroviral treatments (ART)/strategies and followed prospectively. Logistic regression models using generalized estimating equations generated odds ratios (ORs) focusing on the relationship between current CD4 T-cell count (CD4)/HIV-1 RNA viral load (VL) and ADEs in the subsequent 16-week study period. Among the 2948 subjects in the analysis, overall incidence of ADEs was 1.53 per 100 person-years. Multivariate regression models adjusted for demographics, body mass index, and ADE history. A 6-level time-varying variable examined VL (>100,000 copies/mL, < or =100,000) at CD4 levels (0-50, 51-200, >200 cells/microL); reference level was CD4 >200/VL < or =100,000. Among ART naives, odds of having an ADE in the subsequent 16-week interval were greater among subjects with lower CD4 counts; this relationship was modified by VL level (CD4 < or =50/VL >100,000: OR 37.2; C...Continue Reading

References

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Citations

Feb 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E T OvertonP Tebas
Jan 25, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christopher J HoffmannUNKNOWN IeDEA Southern Africa Collaboration
Jan 25, 2011·Journal of Molecular Biology·Celia PeralesEsteban Domingo
Aug 29, 2019·The Journal of the Association of Nurses in AIDS Care : JANAC·Roshna ThapaJu-Hee Nho
Nov 17, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jennifer GillisUNKNOWN CANOC Collaboration

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