PMID: 2488700Feb 1, 1989Paper

Relationship between cell kinetics and radiation-induced arrest of proliferating cells in G2: relevance to efficacy of radiotherapy

Analytical Cellular Pathology : the Journal of the European Society for Analytical Cellular Pathology
D H RutgersI S Wils

Abstract

Monitoring the radiation-induced G2-arrest with flow cytometry disclosed the relationship between the pattern of accumulation in G2 and the cell kinetics (Tc), as assessed with semi-continuous labelling. A close relationship between these two parameters was observed in a murine mammary tumour after high dose-rate irradiation and in human cervix tumours (xenografted and in patients) after low dose-rate irradiation. In inoperable tumours of the oral cavity, a G2-arrest, observed in the first two weeks of fractionated therapy, was found to predict a local cure. Consequently, it was concluded that the cells accumulated in G2 were not doomed cells. This process of radiation-induced synchronization might be exploited in fractionation schemes of which treatment intervals are adjusted to the Tc-related timing of the radiation-induced G2-arrest.

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