Abstract
Cerebral microbleeds (CMBs) have been identified as an important manifestation and diagnostic marker of cerebrovascular disease, but there are also some controversies about the impact of CMBs on cognition. The current cross-sectional study aimed to clarify the relationship between CMBs and cognitive impairment in patients with ischemic cerebrovascular disease. One hundred and fifty patients with lacunar infarction or transient ischemic attack were screened, and all of them were scanned by brain MRI. In the end, 125 patients who were divided into a CMBs group and a non-CMBs group were selected and completed the cognitive tests. Cognitive Function Assessment was performed using the Montreal Cognitive Assessment scale. Images of CMBs were assessed using a susceptibility-weighted imaging measure. Associations between cognitive function and the location of CMBs were determined. There was no significant difference in the demographic and clinical features between the two groups of patients. Compared with participants with no CMBs, the CMBs group showed a greater impairment in cognitive parameters and specifically in performance on three cognitive domains: visual space and executive function, memory, and abstract thinking. Basal gangli...Continue Reading
References
Nov 14, 2012·Molecular and Cellular Neurosciences·Simona DamianoPaolo Mondola
Jan 17, 2013·Stroke; a Journal of Cerebral Circulation·Bhavini PatelHugh S Markus
Feb 5, 2013·Applied Neuropsychology. Adult·Ondrej BezdicekJan Roth
Apr 15, 2014·Psycho-oncology·Michelle LyckePhilip R Debruyne
Jul 13, 2014·Neurology·Kaori MiwaKazuo Kitagawa
Feb 15, 2016·Wilderness & Environmental Medicine·Ian Quigley, Ken Zafren
Sep 7, 2016·Southern Medical Journal·Cody CichowitzSophie Lanzkron
Sep 15, 2016·Stroke; a Journal of Cerebral Circulation·Chih-Ping ChungPei-Ning Wang
Oct 30, 2016·Applied Neuropsychology. Adult·Sandra FreitasIsabel Santana
Sep 22, 2017·PloS One·Xuanting LiWenli Hu
Sep 25, 2017·Scientific Reports·Chih-Ping ChungPei-Ning Wang
Sep 26, 2017·Internal Medicine·Kaoru KinugawaSatoshi Ueno
Dec 10, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D Renard
Dec 15, 2017·Neurology·Chengxuan QiuLenore J Launer
Dec 17, 2017·Stroke; a Journal of Cerebral Circulation·Gargi BanerjeeUNKNOWN CROMIS-2 Collaborators
Jan 26, 2018·PloS One·Serena NannucciLeonardo Pantoni
Jan 27, 2018·Journal of the American Geriatrics Society·Marios K GeorgakisEleni Th Petridou
Feb 16, 2018·Neurology·Aline MendesUNKNOWN PHRC “CAPP” Study Group
Feb 16, 2018·Immunity & Ageing : I & a·Giuseppe GiuglianoValentina Trimarco
Feb 20, 2018·La Radiologia medica·Gianvincenzo SparaciaRoberto Miraglia
Feb 22, 2018·Kardiologiia·Z D KobalavaM A Vorobyeva
Nov 13, 2019·Kardiologiia·Zh D KobalavaSvetlana V Vorobyeva