The purpose of this study was to determine whether a quantitative relationship existed between a reduction in regional myocardial blood flow, measured by radiolabeled microspheres, and the degree and type of changes in myocardial activation recorded in bipolar left ventricular subepicardial and subendocardial electrograms, in open-chest dogs following acute coronary artery occlusion. We found that the degree of regional myocardial ischemia was related quantitatively to the reduction in amplitude recorded with bipolar electrograms in the subepicardium and subendocardium, and to the increase in duration of subepicardial electrograms. Other characteristics measured in electrograms did not relate to the degree of ischemia. Despite a comparable reduction in regional myocardial blood flow, subepicardial conduction delay exceeded that recorded in the subendocardium, which often exhibited accelerated conduction.
Regional Myocardial function in the conscious dog during acute coronary occlusion and responses to morphine, propranolol, nitroglycerin, and lidocaine
Effects of hypoxia, cyanide, and ischaemia on myocardial contraction: observations in isolated muscle and intact heart
Relationship between blood flow to ischemic regions and extent of myocardial infarction. Serial measurement of blood flow to ischemic regions in dogs
Slow ventricular activation in acute myocardial infarction. A source of re-entrant premature ventricular contractions
Characterization and localization of ventricular arrhythmias resulting from myocardial ischemia and infarction
The electrophysiologic time-course of acute myocardial ischemia and the effects of early coronary artery reperfusion
Spontaneous and induced cardiac arrhythmias in subendocardial Purkinje fibers surviving extensive myocardial infarction in dogs
Transmural gradients of glycolytic enzyme activities in left ventricular myocardium. I. The normal state
The electrocardiogram in normal and some abnormal conditions; in revived human fetal heart and in acute and chronic coronary occlusion
Blockade of ATP-sensitive potassium channels by 5-hydroxydecanoate suppresses monophasic action potential shortening during regional myocardial ischemia
The effect of diltiazem on ST-segment elevation and myocardial blood flow distribution during pacing-induced ischemia
Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: role of the transient outward current
Regional changes in blood flow, extracellular potassium and conduction during myocardial ischemia and reperfusion
Functional, structural, and dynamic basis of electrical heterogeneity in healthy and diseased cardiac muscle: implications for arrhythmogenesis and anti-arrhythmic drug therapy
Effect of time interval between repeated brief coronary artery occlusions on arrhythmia, electrical activity and myocardial blood flow
Electrophysiological basis for the antiarrhythmic action and positive inotropy of HA-7, a furoquinoline alkaloid derivative, in rat heart
Electrophysiological mechanisms for antiarrhythmic efficacy and positive inotropy of liriodenine, a natural aporphine alkaloid from Fissistigma glaucescens
Functionally distinct sodium channels in ventricular epicardial and endocardial cells contribute to a greater sensitivity of the epicardium to electrical depression
Increased vulnerability of the subendocardium to ischaemic injury: an electrophysiological explanation
Electrophysiologic and blood-flow responses in the endocardium and epicardium to disopyramide and MS-551 during myocardial ischemia in the dog
Role of NADPH oxidase and xanthine oxidase in mediating inducible VT/VF and triggered activity in a canine model of myocardial ischemia
Association among intracardiac T-wave alternans, ischemia, and spontaneous ventricular arrhythmias after coronary artery occlusion in a canine model
Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges
Ventricular fibrillation during partial reperfusion following severe myocardial ischemia in the canine model
A protective effect of sulphinpyrazone against coronary occlusion-induced shortening of myocardial refractory periods in the rat
Ischemia-induced changes in human endocardial electrograms during percutaneous transluminal coronary angioplasty
Directional variability in the R wave response during serial exercise testing in patients with coronary artery disease
Triggered activity due to delayed afterdepolarizations in sites of focal origin of ischemic ventricular tachycardia
Recent insights pertaining to sarcolemmal phospholipid alterations underlying arrhythmogenesis in the ischemic heart
Ventricular tachycardia with participation of the left bundle-Purkinje system in patients with structural heart disease: identification of slow conduction during sinus rhythm
Transmural reentry triggered by epicardial stimulation during acute ischemia in canine ventricular muscle
Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368
Prevention of ischemic ventricular tachycardia of Purkinje origin: role for alpha(2)-adrenoceptors in Purkinje?
Mechanism of ventricular premature beats elicited by left stellate ganglion stimulation during acute ischaemia of the anterior left ventricle.
Basic Electrophysiologic Mechanisms of Sudden Cardiac Death Caused by Acute Myocardial Ischemia and Infarction
Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.
Cardiac Conduction System
The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.