Relationship between cigarette smoking and hypothyroidism in patients with Hashimoto's thyroiditis

Journal of Endocrinological Investigation
S FukataM Sugawara

Abstract

This retrospective study examined the relationship between smoking history and thyroid function in 387 women patients with Hashimoto's thyroiditis (mean age +/- SD = 50.5 +/- 12.7 yr). The same analysis was done in 238 randomly chosen women patients with nodular goiters (mean age = 45.3 +/- 14 yr) and 166 control women (mean age = 47.7 +/- 14.2 yr). In patients with Hashimoto's thyroiditis, there were 256 non smokers, 110 smokers, and 21 smokers. Among the 110 smoking patients with Hashimoto's thyroiditis, 76.4% were hypothyroid, whereas the prevalence of hypothyroidism was 34.8% among the 256 non smokers. Among the 21 ex-smokers with Hashimoto's thyroiditis, the majority of patients (61.9%) were hypothyroid, suggesting that cessation of smoking does not appear to reverse hypothyroidism. The percentages of smokers in the hypothyroid group, the subclinical hypothyroid group, and the euthyroid group were 45.2%, 18%, and 11.3%, respectively, in patients with Hashimoto's thyroiditis. The greatest serum levels of thiocyanate (an antithyroid substance generated by smoking) were found in those who both smoked and had hypothyroidism. Thus, an increase in serum thiocyanate concentration from smoking may contribute to the development of ...Continue Reading

References

Apr 1, 1978·The Journal of Clinical Endocrinology and Metabolism·P BourdouxA M Ermans
Jun 25, 1992·The New England Journal of Medicine·L TallstedtA Taube
Mar 1, 1992·Clinical Endocrinology·M TellezC Edmonds
May 26, 1990·Lancet·B ShineA P Weetman
Feb 1, 1989·Journal of Endocrinological Investigation·S LioF Monaco
Nov 1, 1989·Journal of Endocrinological Investigation·L BartalenaA Pinchera
Sep 12, 1987·British Medical Journal·E Hägg, K Asplund
Jan 23, 1988·British Medical Journal·H Y FungA M McGregor
Jul 1, 1988·Annals of Clinical Biochemistry·M FalkenssonB Sörbo
Aug 1, 1986·The Journal of Clinical Endocrinology and Metabolism·J TajiriT Sato
Mar 1, 1985·Clinical Endocrinology·L HegedüsU Feldt-Rasmussen
Apr 1, 1971·The Journal of Clinical Endocrinology and Metabolism·L E BravermanF Maloof
Apr 1, 1984·The Journal of Clinical Endocrinology and Metabolism·S B ChristensenA Melander
Apr 1, 1984·Endocrinology·S J WeissE F Grollman
Jan 1, 1981·Acta Medica Scandinavica·A MelanderJ Thorell
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·J B Bertelsen, L Hegedüs
Aug 1, 1993·Acta Endocrinologica·L TallstedtA Taube
Sep 1, 1993·American Journal of Public Health·V L Ernster
Jan 27, 1993·JAMA : the Journal of the American Medical Association·M F Prummel, W M Wiersinga
Feb 1, 1993·Journal of Endocrinological Investigation·E NyströmG Lindstedt
Jan 1, 1964·Physiological Reviews·J WOLFF
Jun 1, 1991·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Mark B Dworkin, Eva Dworkin-Rastl

❮ Previous
Next ❯

Citations

Apr 9, 2005·European Journal of Endocrinology·D Kapoor, T H Jones
Jun 30, 2000·Endocrinology and Metabolism Clinics of North America·A R AyalaP W Ladenson
Sep 8, 2015·Neuroscience and Biobehavioral Reviews·Prescott T Leach, Thomas J Gould
Nov 2, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Prescott T LeachThomas J Gould
Aug 19, 2007·Thyroid : Official Journal of the American Thyroid Association·Elias E MazokopakisEmmanuel S Ganotakis
Feb 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Peter VestergaardLeif Mosekilde
May 1, 1998·Journal of Clinical Gastroenterology·S A ShahJ A Pallotta
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Fabrizio Guarneri, Salvatore Benvenga
Jun 27, 2003·The New England Journal of Medicine·Elizabeth N PearceLewis E Braverman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.