Relationship between circulating CD4+ T lymphocytes and cognitive impairment in patients with Parkinson's disease.

Brain, Behavior, and Immunity
Luca MagistrelliFranca Marino

Abstract

Parkinson's disease (PD) is characterized by loss of dopaminergic neurons. Neuroinflammation may represent an important factor in the pathophysiology of PD and recent findings indicate that PD patients present a pro-inflammatory peripheral profile of CD4+ T lymphocytes, which may correlate with motor disability. However, no data are currently available on the relationship between CD4+ T lymphocytes and cognitive function in PD. The aim of our study is to evaluate the relationship between cognitive profile and circulating CD4+ T lymphocyte subsets in PD patients. PD patients underwent blood withdrawal and CD4+ T lymphocyte subpopulations, including CD4+ T naïve and memory cells, Th1, Th2, Th17, Th1/17 and T regulatory (Treg) cells were evaluated by flow cytometry. Cognitive evaluation was performed using Addenbrooke Cognitive Examination (ACE-R). 43 consecutive PD patients (31 males; age [mean ± SD]: 68.9 ± 8.4 years) were enrolled. 14/43 (32.6%) were drug naïve. Based on the ACE-R score, patients were divided in two groups using defined cutoff values. In comparison to patients with normal cognitive profile, patients with cognitive impairment had a higher number of circulating lymphocytes. Moreover, drug naïve patients with a wo...Continue Reading

References

Oct 1, 1988·Annals of Neurology·P L McGeerE G McGeer
Sep 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease
Aug 11, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·George K Tofaris, Maria Grazia Spillantini
Nov 26, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Movement Disorder Society UPDRS Revision Task Force
Dec 4, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M A ReyesM Merello
Feb 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ashley D ReynoldsHoward E Gendelman
Jul 14, 2010·Brain, Behavior, and Immunity·C HeesenS M Gold
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Jun 3, 2011·European Journal of Epidemiology·Karin WirdefeldtJack Mandel
Jun 10, 2011·Acta Neurologica Scandinavica·M RentzosI Evdokimidis
Jul 12, 2011·Parkinsonism & Related Disorders·K Ray ChaudhuriPablo Martinez-Martin
Jun 27, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Peter McColganCaroline H Williams-Gray
Oct 12, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jessica A Hutter SaundersHoward E Gendelman
Aug 21, 2014·Dementia and Geriatric Cognitive Disorders·Jin-Mei ChenQi Cheng
Dec 3, 2014·Parkinsonism & Related Disorders·C ComiA Antonini
Apr 24, 2015·Lancet·Lorraine V Kalia, Anthony E Lang
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaGünther Deuschl
Feb 26, 2016·Brain : a Journal of Neurology·Cira DansokhoGuillaume Dorothée
Mar 22, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Caroline H Williams-GrayUNKNOWN ICICLE-PD study group
Mar 8, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yan HuangYu-Ping Peng
Jun 7, 2017·Journal of Alzheimer's Disease : JAD·Mandy BusseStefan Busse
Aug 27, 2015·NPJ Parkinson's Disease·Florian BruggerKailash P Bhatia
Apr 18, 2018·Frontiers in Neurology·Lucia CorradoCristoforo Comi
Jan 24, 2019·British Journal of Pharmacology·Claudia CristianoFrancesco Maione
Feb 9, 2019·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kun NieLijuan Wang
Mar 13, 2019·Neuropsychiatric Disease and Treatment·Diana Bruno, Sofia Schurmann Vignaga
May 28, 2019·Frontiers in Immunology·Luca MagistrelliCristoforo Comi
Nov 30, 2019·Frontiers in Aging Neuroscience·Davide Maria CammisuliCarlo Pruneti

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Citations

May 1, 2021·International Journal of Molecular Sciences·Luca MagistrelliFranca Marino
May 18, 2021·Frontiers in Aging Neuroscience·Xueping ChenHuifang Shang
Jul 22, 2021·Annals of Clinical and Translational Neurology·Qingwei YangZhongjie Chen
Aug 7, 2021·Metabolic Brain Disease·Ankit UniyalVinod Tiwari

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