Relationship between circulating irisin levels and overweight/obesity: A meta-analysis

World Journal of Clinical Cases
Jue JiaYong-Qin Shi

Abstract

Currently, the findings about irisin as a novel myokine related to obesity are inconsistent in overweight/obese people. To our knowledge, no systematic analysis has been conducted to evaluate the relationship between irisin levels and overweight/obesity. To evaluate the association between circulating irisin levels and overweight/obesity. The Cochrane Library, MEDLINE, SCOPUS, and the ISI Web of Science were searched to retrieve all of the studies associated with circulating irisin levels and overweight/obesity. Standard mean difference values and 95% confidence intervals (CI) were estimated and pooled using meta-analysis methodology. A total of 18 studies were included in our meta-analysis containing 1005 cases and 1242 controls. Our analysis showed that the circulating irisin level in overweight/obese people was higher than that in overall healthy controls (random effects MD = 0.63; 95%CI: 0.22-1.05; P = 0.003). In the subgroup analysis by ethnicity, the irisin level was higher in overweight/obesity people than that in controls in Africa (random effects MD = 3.41; 95%CI: 1.23-5.59; P < 0.05) but not in European, Asian, or American populations. In addition, in a subgroup analysis by age, the results showed that obese children ...Continue Reading

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Citations

Apr 23, 2020·Journal of Clinical Medicine·Laurent MaïmounAriane Sultan
Sep 22, 2020·TheScientificWorldJournal·Farah A RashidHana'a Addai Ali
Jul 28, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Serpil Erşan, Etem Erdal Erşan
Jan 26, 2021·Endocrine Reviews·Steffen MaakHarold P Erickson
Apr 8, 2021·Archives of Endocrinology and Metabolism·Bruno Halpern
May 8, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Rui Wang, Hongyan Liu
May 20, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Nadeeja Niranjalie Wijayatunga, Emily Jane Dhurandhar
Aug 24, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhe-Bin ChengChi Zhang

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Methods Mentioned

BETA
ELISA
Enzyme-linked immunosorbent assay

Software Mentioned

Stata
Review Manager

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