Relationship between Clinical and Immunological Features of Thyroid Autoimmunity and Ophthalmopathy during Pregnancy

Journal of Thyroid Research
Jack R WallBernard Champion

Abstract

Problem. Clinical features of Graves' hyperthyroidism (GH) generally improve during pregnancy and rebound in the postpartum period. It is unclear whether the ophthalmopathy that is associated with GH and, less often, Hashimoto's thyroiditis (HT) changes in parallel with the thyroid associated antibody reactions and clinical features or runs a different course. Method of Study. We retrospectively studied 19 patients with autoimmune thyroid disease over 22 pregnancies: 9 pregnancies with GH and 13 with HT. Ophthalmopathy was defined by NOSPECS class. Results. Thyroid peroxidase (TPO) and thyroglobulin (Tg) antibody titres decreased during pregnancy and rose in the postpartum period. During pregnancy, 5 patients with GH and 4 patients with HT developed mild ophthalmopathy and two patients with GH and HT developed new upper eyelid retraction (UER). In the postpartum period, eye scores improved in 3 patients with GH and 3 with HT, remained stable in two and 5 patients, respectively, and worsened in 2 patients with GH and one with HT. Conclusions. In patients with mild to moderate eye signs associated with GH and HT, the orbital and thyroid reactions ran different courses during pregnancy. Since no patient had severe ophthalmopathy, ...Continue Reading

References

Aug 1, 1989·The British Journal of Ophthalmology·M P MouritsR van der Gaag
Oct 1, 1969·American Journal of Ophthalmology·S C Werner
Jun 1, 1993·Ophthalmic Plastic and Reconstructive Surgery·W R NuneryT J Gavin
Mar 21, 1998·Journal of Leukocyte Biology·J P Buyon
Nov 9, 2000·The New England Journal of Medicine·A P Weetman
Feb 24, 2001·Critical Reviews in Clinical Laboratory Sciences·M YamadaJ R Wall
Dec 19, 2002·Thyroid : Official Journal of the American Thyroid Association·Wilmar M Wiersinga, Luigi Bartalena
May 29, 2004·Journal of Endocrinological Investigation·L HegediüsP Vestergaard
Jul 31, 2008·The Journal of Clinical Endocrinology and Metabolism·Mario RotondiLuca Chiovato
Feb 12, 2010·Thyroid : Official Journal of the American Thyroid Association·Hilman TjiangJack R Wall
Nov 25, 2011·Obstetrical & Gynecological Survey·Alan N BaerMichelle Petri
Apr 9, 2014·The Journal of Clinical Endocrinology and Metabolism·Roshini FernandoTerry J Smith

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Citations

Dec 16, 2020·BMC Endocrine Disorders·Janos K AranyosiBernadett Ujhelyi

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SigmaStat

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