Relationship Between Collateral Status, Contrast Transit, and Contrast Density in Acute Ischemic Stroke

Stroke; a Journal of Cerebral Circulation
Hiroyuki KawanoC R Levi

Abstract

Collateral circulation is recognized to influence the life expectancy of the ischemic penumbra in acute ischemic stroke. The best method to quantify collateral status on acute imaging is uncertain. We aimed to determine the relationship between visual collateral status, quantitative collateral assessments, baseline computed tomographic perfusion measures, and tissue outcomes on follow-up imaging. Sixty-six consecutive patients with acute ischemic stroke clinically eligible for recanalization therapy and with M1 or M2 middle cerebral artery occlusion were evaluated. We compared the visual collateral scoring with measures of contrast peak time delay and contrast peak density. We also compared these measures for their ability to predict perfusion lesion and infarct core volumes, final infarct, and infarct growth. Shorter contrast peak time delay (P=0.041) and higher contrast peak density (P=0.002) were associated with good collateral status. Shorter contrast peak time delay correlated with higher contrast peak density (β=-4.413; P=0.037). In logistic regression analysis after adjustment for age, sex, onset-computed tomographic time, and occlusion site, higher contrast peak density was independently associated with good collateral ...Continue Reading

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Citations

Feb 12, 2017·Stroke; a Journal of Cerebral Circulation·Yu-Chieh Jill KaoYen-Yu Ian Shih
Jul 3, 2019·Journal of Translational Medicine·Chuan QinDai-Shi Tian
Sep 2, 2020·The European Journal of Neuroscience·Abina Vishni RavindranSonu Bhaskar
Dec 14, 2017·International Journal of Molecular Sciences·Mohamad El Amki, Susanne Wegener
Nov 4, 2020·Translational Stroke Research·Yinghua JiangXiaoying Wang
Jun 16, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Gao MaFei-Yun Wu
Nov 20, 2021·International Journal of Stroke : Official Journal of the International Stroke Society·Gabriel M RodriguesRaul G Nogueira

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