Relationship Between Cotinine-Verified Smoking Status and Incidence of Hypertension in 74,743 Korean Adults

Circulation Journal : Official Journal of the Japanese Circulation Society
Byung Jin KimJin Ho Kang

Abstract

The relationship between chronic smoking and hypertension (HTN) is inconclusive in previous studies, which were mainly based on self-reported smoking status. The aim of this study was to evaluate the association of cotinine-verified smoking status with incident HTN.Methods and Results:A total of 74,743 participants (43,104 men; age 38±5.4 years) were included in the study, with a mean follow-up period of 29 months. Individuals were divided into 4 groups on the basis of their cotinine-verified smoking status at baseline and at follow-up (never-smoking, new-smoking, former-smoking, and sustained-smoking). The incidence rate of HTN in the never-smoking, new-smoking, former-smoking, and sustained-smoking groups was 8.2%, 7.6%, 10.1%, and 8.7% for men and 1.8%, 2.5%, 1.5%, and 2.2% for women, respectively. In a multivariate Cox-hazard regression analysis adjusted for the variables with a univariate relationship, new-smoking and sustained-smoking had decreased relative risks (RRs) for incident HTN compared with never-smoking (RR [95% CI], 0.75 [0.58, 0.96] for new-smoking and 0.82 [0.74, 0.90] for sustained-smoking). Cotinine-verified current smoking at baseline was also inversely associated with incident HTN compared with cotinine-v...Continue Reading

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Citations

Jun 27, 2019·International Journal of Environmental Research and Public Health·Yongho JeeSung-Il Cho
Apr 24, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshiaki Ebina
Aug 31, 2020·Journal of Korean Medical Science·Sung Ho LeeSeung Jae Lee
Sep 25, 2020·American Journal of Hypertension·Robert C KaplanNora Franceschini
Nov 2, 2021·Frontiers in Cardiovascular Medicine·Bi-Liu WeiPeng-Fei Zheng

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