Relationship between Decrease in Serum Sodium Level and Bone Mineral Density in Osteoporotic Fracture Patients

Journal of Bone Metabolism
Mi Kyung KwakDong Won Byun

Abstract

Recently, it has been suggested that decrease in serum sodium level is associated with osteoporosis. However, no study in Korea has reported the association of decrease in serum sodium level with osteoporosis. In this study, we investigated the relationship between the decrease in serum sodium level and severity of osteoporotic fracture in patients. We enrolled 290 subjects who were admitted and operated at Soonchunhyang University Hospital due to major fractures. For the control group, we enrolled 1,027 subjects who visited a health promotion center. We carried a 1:1 matching with age and sex from the case group. In a total of 164 age- and sex-matched subjects, serum sodium level was significantly lower in the fracture group than in the non-fracture group (P=0.001). Serum sodium level was significantly lower in the severe osteoporosis group than that in the non-severe osteoporosis group (P=0.002). Old age and decrease in serum sodium level were independent risk factors of osteoporosis (odds ratio [OR]=1.088, P=0.008, confidence interval [CI]=[1.022-1.157]; OR= 0.840, P=0.037, CI=0.713-0.989). Serum sodium level was significantly lower in the fracture group than that in the non-fracture group and in the severe osteoporosis grou...Continue Reading

References

Jul 31, 1998·Lancet·S Kumar, T Berl
Aug 26, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K M SandersM A Kotowicz
Jun 21, 2001·JAMA : the Journal of the American Medical Association·E L HannanA L Siu
Jun 7, 2002·Lancet·Steven R Cummings, L Joseph Melton
Oct 22, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Robert C Hawkins
Jul 18, 2006·The American Journal of Medicine·Ashish UpadhyayNicolaos E Madias
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
May 28, 2009·International Urology and Nephrology·Harminder S SandhuMichael F Michelis
Jan 9, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Sinead KinsellaJoseph A Eustace
Jul 6, 2011·Annals of Internal Medicine·Steven Goodman, Kay Dickersin
Oct 26, 2011·Nature Reviews. Endocrinology·Ewout J HoornM Carola Zillikens
Nov 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Juan Carlos AyusMichael L Moritz
Feb 16, 2013·Archives of Orthopaedic and Trauma Surgery·Tetsuo HaginoHirotaka Haro
Mar 26, 2013·Journal of the American Heart Association·Antonios H TzamaloukasJoseph I Shapiro

❮ Previous
Next ❯

Citations

Nov 26, 2016·Acta Clinica Belgica·Fabrice Gankam Kengne

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Frontiers in Bioengineering and Biotechnology
Fatemeh Radaei, Shahriar Gharibzadeh
Archives of Internal Medicine
Michael C SheppardJayne A Franklyn
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
S YangT V Nguyen
© 2021 Meta ULC. All rights reserved