Abstract
The features of behavioural and psychological symptoms of dementia (BPSD) are influenced by dementia stage. In early-onset Alzheimer's disease (EOAD), the association between BPSD and dementia stage remains unclear because of the difficulty of recruiting subjects with a wide range of disease severity. We used a combination of community-based and hospital-based approaches to investigate the relationship between dementia severity and BPSD in EOAD patients. Sixty-three consecutive EOAD outpatients and 29 EOAD patients from a community-based survey were divided into three dementia severity groups according to the Clinical Dementia Rating scale (CDR): mild (CDR 0.5-1, n = 55), moderate (CDR 2, n = 17), and severe (CDR 3, n = 20). BPSD were rated using the Neuropsychiatric Inventory. Scores of the Neuropsychiatric Inventory subscales agitation, euphoria, apathy, disinhibition, irritability, and aberrant motor behaviour increased significantly with increased dementia severity. Hallucinations were greater in the moderate group than in the mild group. For delusions, depression, and anxiety, no significant differences were observed among the three severity groups. The pattern of apathy, agitation, disinhibition, irritability, and aberran...Continue Reading
References
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Aug 1, 1990·The American Journal of Psychiatry·C SteeleM Folstein
Jul 1, 1984·Neurology·G McKhannE M Stadlan
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Dec 1, 1994·Neurology·J L CummingsJ Gornbein
Jan 1, 1996·Neurology·M S MegaJ Gornbein
Feb 3, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·C G LyketsosA Warren
Feb 23, 1999·Dementia and Geriatric Cognitive Disorders·G B FrisoniJ L Cummings
Feb 19, 2000·International Journal of Geriatric Psychiatry·T González-SalvadorC Steele
Apr 28, 2000·The American Journal of Psychiatry·C G LyketsosJ C Breitner
May 24, 2000·International Journal of Geriatric Psychiatry·D G HarwoodR Duara
Mar 23, 2001·Annals of Neurology·S TekinJ L Cummings
Aug 21, 2003·The Journal of Neuropsychiatry and Clinical Neurosciences·Oscar L LopezSteven T DeKosky
May 1, 1953·A.M.A. Archives of Neurology and Psychiatry·M A NEUMANN, R COHN
Mar 19, 2005·Dementia and Geriatric Cognitive Disorders·Maristella PiccininniDomenico Inzitari
May 28, 2005·International Journal of Geriatric Psychiatry·Pauline AaltenFrans R J Verhey
Jun 21, 2005·Journal of the Neurological Sciences·S SrikanthE Ratnavalli
Mar 9, 2007·International Journal of Geriatric Psychiatry·Yasutaka ToyotaHirotaka Tanabe
Apr 6, 2007·International Journal of Psychiatry in Medicine·Mario F Mendez
Nov 8, 2007·Dementia and Geriatric Cognitive Disorders·Pauline AaltenPhilippe H Robert
Mar 28, 2008·Acta Psychiatrica Scandinavica·M CaputoP Mecocci
Apr 1, 1948·The Journal of Mental Science·R D NEWTON
Nov 13, 2009·International Psychogeriatrics·Claire ThompsonPerminder Sachdev
Apr 9, 2010·Dementia and Geriatric Cognitive Disorders·Tetsuo KashibayashiSatoshi Tanimukai
Sep 3, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Gianfranco SpallettaKatie Palmer
Mar 19, 2013·Journal of Neurology·Marco CanevelliUNKNOWN ICTUS/DSA Group
Jan 1, 2014·Psychiatry and Clinical Neurosciences·Chiaki IkejimaTakashi Asada
Citations
Feb 18, 2016·Aging & Mental Health·Shuling LiuYong Ji
Jan 28, 2016·Alzheimer's Research & Therapy·Monica H BreitveArvid Rongve
Oct 19, 2017·Journal of Alzheimer's Disease : JAD·Aditi JoshiMario F Mendez
Mar 7, 2018·Issues in Mental Health Nursing·Lisa L OnegaLora Epperly
Sep 21, 2016·Journal of Geriatric Psychiatry and Neurology·Pongsatorn PaholpakMario F Mendez
Oct 30, 2018·Korean journal of family medicine·Sunyoung ParkJinyoung Shin
Apr 3, 2019·American Journal of Alzheimer's Disease and Other Dementias·Sarah BaillonLatha Velayudhan
Jun 1, 2017·Dementia and Neurocognitive Disorders·Yong Tae KwakMin-Seong Koo
Feb 8, 2020·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Shin-Chiao TienChun-Chi Hsu
Jul 21, 2020·International Psychogeriatrics·Jessica D CollinsAida Suárez-González
Mar 12, 2019·International Psychogeriatrics·Milena AnatchkovaMyrlene Sanon Aigbogun
Nov 21, 2019·Aging & Mental Health·Adrie A J GerritsenRaymond T C M Koopmans
Oct 22, 2019·Frontiers in Neurology·Antti CajanusAnette Hall
May 2, 2017·Clinical Gerontologist·Jocelyn Shealy McGeeSteffi Marotzke Kim
Dec 7, 2017·American Journal of Alzheimer's Disease and Other Dementias·Maria do Céu FerreiraAna Sofia Costa
Jan 27, 2019·Medicine·Shun-Ku LinJung-Nien Lai
Oct 1, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Daniel R BatemanUNKNOWN International Society to Advance Alzheimer's Research and Treatment (ISTAART), Neuropsychiatric Syndromes Professional Inter
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·David A Loeffler
Nov 21, 2020·Journal of Alzheimer's Disease : JAD·Bing YangQinghua Zhao
Apr 7, 2021·Archives of Gerontology and Geriatrics·Ayami MeguroHirohiko Hirano
Apr 22, 2021·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Pietro CappellettoCamilla Ferrari
Dec 7, 2018·Journal of the American Medical Directors Association·Yacine JaïdiRachid Mahmoudi
May 14, 2021·JAD Reports·Mario F Mendez
Jul 6, 2021·World Journal of Clinical Cases·De-Wei WangPing Wang
Jun 23, 2020·Journal of the American Medical Directors Association·Di YanShubing Cai
Jul 13, 2021·Journal of Alzheimer's Disease : JAD·Eddie JonesJoseph Husbands
Oct 31, 2021·Advances in Therapy·Wei JiangYaxing Gui
Dec 5, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Neus FalgàsChristine M Walsh