Relationship between dementia severity and behavioural and psychological symptoms in early-onset Alzheimer's disease

Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society
Hibiki TanakaManabu Ikeda

Abstract

The features of behavioural and psychological symptoms of dementia (BPSD) are influenced by dementia stage. In early-onset Alzheimer's disease (EOAD), the association between BPSD and dementia stage remains unclear because of the difficulty of recruiting subjects with a wide range of disease severity. We used a combination of community-based and hospital-based approaches to investigate the relationship between dementia severity and BPSD in EOAD patients. Sixty-three consecutive EOAD outpatients and 29 EOAD patients from a community-based survey were divided into three dementia severity groups according to the Clinical Dementia Rating scale (CDR): mild (CDR 0.5-1, n = 55), moderate (CDR 2, n = 17), and severe (CDR 3, n = 20). BPSD were rated using the Neuropsychiatric Inventory. Scores of the Neuropsychiatric Inventory subscales agitation, euphoria, apathy, disinhibition, irritability, and aberrant motor behaviour increased significantly with increased dementia severity. Hallucinations were greater in the moderate group than in the mild group. For delusions, depression, and anxiety, no significant differences were observed among the three severity groups. The pattern of apathy, agitation, disinhibition, irritability, and aberran...Continue Reading

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Citations

Jan 28, 2016·Alzheimer's Research & Therapy·Monica H BreitveArvid Rongve
Oct 19, 2017·Journal of Alzheimer's Disease : JAD·Aditi JoshiMario F Mendez
Mar 7, 2018·Issues in Mental Health Nursing·Lisa L OnegaLora Epperly
Sep 21, 2016·Journal of Geriatric Psychiatry and Neurology·Pongsatorn PaholpakMario F Mendez
Apr 3, 2019·American Journal of Alzheimer's Disease and Other Dementias·Sarah BaillonLatha Velayudhan
Jun 1, 2017·Dementia and Neurocognitive Disorders·Yong Tae KwakMin-Seong Koo
Feb 8, 2020·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Shin-Chiao TienChun-Chi Hsu
Mar 12, 2019·International Psychogeriatrics·Milena AnatchkovaMyrlene Sanon Aigbogun
Nov 21, 2019·Aging & Mental Health·Adrie A J GerritsenRaymond T C M Koopmans
May 2, 2017·Clinical Gerontologist·Jocelyn Shealy McGeeSteffi Marotzke Kim
Dec 7, 2017·American Journal of Alzheimer's Disease and Other Dementias·Maria do Céu FerreiraAna Sofia Costa
Oct 1, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Daniel R BatemanUNKNOWN International Society to Advance Alzheimer's Research and Treatment (ISTAART), Neuropsychiatric Syndromes Professional Inter
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·David A Loeffler
Apr 7, 2021·Archives of Gerontology and Geriatrics·Ayami MeguroHirohiko Hirano
Apr 22, 2021·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Pietro CappellettoCamilla Ferrari
Dec 7, 2018·Journal of the American Medical Directors Association·Yacine JaïdiRachid Mahmoudi
May 14, 2021·JAD Reports·Mario F Mendez
Jul 13, 2021·Journal of Alzheimer's Disease : JAD·Eddie JonesJoseph Husbands
Dec 5, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Neus FalgàsChristine M Walsh

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