Relationship between depression and C-reactive protein in a screening population

Psychosomatic Medicine
Kevin M DouglasPatrick G O'Malley

Abstract

Both depression and C-reactive protein (CRP) are markers of increased risk for cardiovascular events. This study examined the relationship between CRP and depression in a cohort of participants undergoing a periodic physical to assess potential for interaction as either mediation or confounding of effect on cardiovascular risk. We conducted a cross-sectional study of a cohort of 696 consenting, active duty US Army personnel undergoing a periodic physical. We measured depression using the Patient Health Questionnaire-9, the depression module of the self-administered version of the Primary Care Evaluation of Mental Disorders (PRIME-MD). We used a highly sensitive assay to measure CRP. The mean age in the cohort was 44 years (SD +/- 3; 82% male). The mean CRP level was 1.7 mg/l (range, 0.3-9.9; SD +/- 1.6 mg/l). Depression scores ranged from 0 to 26 with a mean of 2 (SD +/- 3). Depression scores correlated with prevalences of major depressive disorder and of any depressive disorder of 3.3% and 15%, respectively. Depression scores correlated positively with CRP levels (r = 0.085; p =.028), as did other variables known to be associated with CRP: body mass index (BMI; r = 0.36), insulin levels (r = 0.22), mean arterial pressure (r = ...Continue Reading

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