Relationship between Diabetes and Diabetes Medications and Risk of Different Molecular Subtypes of Breast Cancer

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Hongjie ChenChristopher I Li

Abstract

Type II diabetes and certain diabetes treatments have been observed to impact breast cancer risk. However, their associations with different breast cancer molecular subtype defined by estrogen receptor (ER)/progesterone receptor (PR)/HER2 status are unclear. We conducted a retrospective multi-center population-based case-case study consisting of 4,557 breast cancer cases to evaluate the impact of type II diabetes and diabetes medications on the risk of different breast cancer molecular subtypes [ER+/HER2-, ER+/HER2+, triple negative (ER-/PR-/HER2-), and HER2 overexpressing (H2E, ER-/PR-/HER2+)]. Using ER+/HER2- cases as the reference group, we estimated ORs and corresponding 95% confidence intervals (CI) for each subtype using polytomous logistic regression. Compared with those without a diabetes history, women with type II diabetes had a 38% (95% CI, 1.01-1.89) increased odds of triple-negative breast cancer (TNBC). Current and longer term recent metformin use (13-24 months of treatment within the 24-month period prior to breast cancer diagnosis) was associated with elevated odds of TNBC (OR = 1.54; 95% CI, 1.07-2.22 and OR = 1.80; 95% CI, 1.13-2.85, respectively). The odds of having a triple-negative rather than ER+/HER2- bre...Continue Reading

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Citations

Nov 20, 2020·Expert Opinion on Drug Safety·Shahariar Mohammed FahimChiahung Chou
Oct 24, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jean A McDougallChristopher I Li
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Feb 20, 2021·Frontiers in Oncology·Tiffany ScullyEmily Jane Gallagher
Mar 8, 2021·Breast Cancer Research and Treatment·Juhua LuoJean Wactawski-Wende
Apr 13, 2021·Frontiers in Oncology·Shuwen DongXiaosong Chen
Jan 1, 2020·Seminars in Cancer Biology·Lothar C Dieterich, Andreas Bikfalvi

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