Relationship Between Diastolic Dysfunction and Atherosclerosis and Vascular Calcification in Hemodialysis Patients: Diagnostic Potential of the Cardio-Ankle Vascular Index

Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Kohei UnagamiKazumichi Matsushita

Abstract

Diastolic dysfunction (DD) commonly causes heart failure with preserved ejection fraction (EF). Here, we examine associations between DD severity and atherosclerosis/vascular calcification in hemodialysis patients. Echocardiography was performed on 101 patients undergoing hemodialysis therapy. Twelve patients (EF < 50% or chronic atrial fibrillation) were excluded; DD of the remaining 89 patients was classified into four grades. We then investigated the relationship between their DD grades and the cardio-ankle vascular index (CAVI), ankle-brachial pressure index (ABI), toe-brachial pressure index (TBI), and aortic calcification area index (ACAI). Seventy-seven patients (86.5%) with EF ≥ 50% had DD. Associations with advanced age and comorbid diabetes mellitus and cardiovascular disease were observed. The CAVI, TBI, and ACAI, but not ABI, increased proportionally with DD grades. Thus, many hemodialysis patients developed DD, with systolic function maintained. Strong associations between DD grades and progression of both atherosclerosis and vascular calcification could be inferred.

References

Mar 24, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K DemuthG M London
Jan 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gerard M London
Apr 2, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kosaku NittaHiroshi Nihei
Apr 15, 2004·The American Journal of Cardiology·Steffen BrucksDavid C Sane
May 7, 2004·The New England Journal of Medicine·Michael R ZileWilliam H Gaasch
Sep 1, 2004·Journal of the American College of Cardiology·R Christopher JonesMichael S Lauer
Mar 10, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tomoyuki YambeTakashi Kuwayama
Apr 19, 2006·Circulation·Loek van HeerebeekWalter J Paulus
Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Jul 21, 2006·The New England Journal of Medicine·R Sacha BhatiaPeter P Liu
Sep 2, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Atsuhiro IchiharaHiroshi Itoh
Sep 20, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Ayuko FujiuKosaku Nitta
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Feb 6, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuhiro YamamotoToshiaki Mano
May 23, 2012·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Akihiko KatoHiromichi Kumagai
Feb 19, 2013·Heart & Lung : the Journal of Critical Care·Mehmet AydoganMurat Unlu

❮ Previous
Next ❯

Citations

Jan 8, 2013·Peptides·Yu-Bin SuiYong-Fen Qi
May 27, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yingzi HuangHongqi Ren
Aug 17, 2021·Journal of cardiology·Toru Miyoshi, Hiroshi Ito

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.