Abstract
Diastolic dysfunction (DD) commonly causes heart failure with preserved ejection fraction (EF). Here, we examine associations between DD severity and atherosclerosis/vascular calcification in hemodialysis patients. Echocardiography was performed on 101 patients undergoing hemodialysis therapy. Twelve patients (EF < 50% or chronic atrial fibrillation) were excluded; DD of the remaining 89 patients was classified into four grades. We then investigated the relationship between their DD grades and the cardio-ankle vascular index (CAVI), ankle-brachial pressure index (ABI), toe-brachial pressure index (TBI), and aortic calcification area index (ACAI). Seventy-seven patients (86.5%) with EF ≥ 50% had DD. Associations with advanced age and comorbid diabetes mellitus and cardiovascular disease were observed. The CAVI, TBI, and ACAI, but not ABI, increased proportionally with DD grades. Thus, many hemodialysis patients developed DD, with systolic function maintained. Strong associations between DD grades and progression of both atherosclerosis and vascular calcification could be inferred.
References
Mar 1, 1995·Kidney International·J D HarnettP S Parfrey
Mar 24, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K DemuthG M London
Jan 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gerard M London
Jun 14, 2002·Cardiovascular Research·Kazuhiro YamamotoMasatsugu Hori
Dec 17, 2003·The American Journal of Cardiology·Philip M MottramThomas H Marwick
Apr 2, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kosaku NittaHiroshi Nihei
Apr 15, 2004·The American Journal of Cardiology·Steffen BrucksDavid C Sane
May 7, 2004·The New England Journal of Medicine·Michael R ZileWilliam H Gaasch
Sep 1, 2004·Journal of the American College of Cardiology·R Christopher JonesMichael S Lauer
Mar 10, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tomoyuki YambeTakashi Kuwayama
Apr 19, 2006·Circulation·Loek van HeerebeekWalter J Paulus
Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Jul 21, 2006·The New England Journal of Medicine·R Sacha BhatiaPeter P Liu
Apr 17, 2008·European Heart Journal·Michael R MacDonaldUNKNOWN CHARM Investigators
Sep 2, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Atsuhiro IchiharaHiroshi Itoh
Sep 20, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Ayuko FujiuKosaku Nitta
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Feb 6, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuhiro YamamotoToshiaki Mano
Jun 10, 2009·Circulation·Douglas S LeeDaniel Levy
Jul 25, 2009·Journal of the American College of Cardiology·Samer S Najjar
Oct 10, 2009·Nephron. Clinical Practice·Akihiko KatoAkira Hishida
Aug 19, 2011·Clinical and Experimental Nephrology·Masaki OhyaTakashi Shigematsu
May 23, 2012·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Akihiko KatoHiromichi Kumagai
Aug 10, 2012·Journal of Korean Medical Science·Hye Eun YoonSeok Joon Shin
Sep 6, 2012·Kidney & Blood Pressure Research·Won Suk AnYoung Ki Son
Feb 19, 2013·Heart & Lung : the Journal of Critical Care·Mehmet AydoganMurat Unlu
Citations
Jan 8, 2013·Peptides·Yu-Bin SuiYong-Fen Qi
Sep 10, 2016·Scientific Reports·Szu-Chia ChenHung-Chun Chen
Oct 22, 2016·Renal Failure·Zhen WangBing-Qing Deng
May 27, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yingzi HuangHongqi Ren
Aug 17, 2021·Journal of cardiology·Toru Miyoshi, Hiroshi Ito