Relationship between diastolic hypertension and myocardial morphology and function in elderly males with diabetes mellitus

Diabetologia
L LindH O Lithell

Abstract

The existence of a distinct diabetic cardiomyopathy, characterized by a raised left ventricular mass, has previously been suggested. However, as diabetes mellitus is associated with both left ventricular hypertrophy and hypertension a confounding effect of raised blood pressure in diabetic patients has to be considered. In the present cross-sectional study an echocardiographical examination was performed as part of a health screening survey in 582 males, aged 70 years. After the exclusion of subjects with coronary heart disease or those on regular antihypertensive treatment, 30 normotensive subjects with diabetes were compared with 10 subjects with non-insulin-dependent diabetes (NIDDM) and a diastolic blood pressure 90 mm Hg or more and 203 normotensive control subjects with normal glucose tolerance. Both groups with NIDDM showed a significantly increased left atrial diameter (4.4 +/- 0.7 vs 4.0 +/- 0.5 cm, p < 0.05) and an increased atrial component in diastole (A-wave, p < 0.01) compared to the control subjects. Left ventricular mass was, however, only marginally and not significantly elevated in the diabetic subjects when compared to the healthy control subjects (133 +/- 19 and 133 +/- 28 vs 128 +/- 25 g/m2). Only in the su...Continue Reading

Citations

Apr 18, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuji ShigematsuJitsuo Higaki
Aug 24, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D QuilliotF Zannad
Nov 5, 2008·Biological & Pharmaceutical Bulletin·Chun-Hong ZhangWei-Jin Zang
Jun 1, 2011·Heart Failure Reviews·Inês Falcão-Pires, Adelino F Leite-Moreira
Aug 19, 2007·Diabetes & Metabolism·C Verny
Aug 20, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·N H AndersenC E Mogensen
Nov 24, 2012·Human & Experimental Toxicology·B R Goyal, A A Mehta
Aug 6, 2004·Endocrine Reviews·Zhi You FangThomas H Marwick
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Yukitaka ShizukudaPeter M Buttrick

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