PMID: 3773574Aug 1, 1986Paper

Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium

Mechanisms of Ageing and Development
M L KatzW G Robison

Abstract

A variety of evidence suggests that autoxidation of cellular components probably plays a significant role in the age-related accumulation of lipofuscin, or age-pigment, in the mammalian retinal pigment epithelium (RPE). Among the likely candidates for conversion into RPE lipofuscin fluorophores via autoxidative mechanisms are vitamin A compounds, which are present in the retina and RPE in high concentrations. Vitamin E, an important lipid antioxidant, is likely to inhibit vitamin A autoxidation. Experiments were conducted to evaluate the significance of vitamin A autoxidation in the deposition of lipofuscin in the RPE. Albino rats were fed diets either supplemented with or lacking vitamin E. Each of these two groups of animals was further subdivided into three groups which were fed different levels of vitamin A palmitate: none, 14.0 mumol/kg diet, and 80.5 mumol/kg diet. After 26 weeks, the animals were killed and the RPE lipofuscin contents were determined by both fluorescence measurements and quantitative ultrastructural morphometry. Vitamin A palmitate deficiency led to significant reductions in RPE lipofuscin deposition, relative to the amounts of this pigment present in the groups receiving vitamin A palmitate in their die...Continue Reading

References

Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·R K HerrmannM Spitznas
Feb 1, 1984·Experimental Eye Research·M L Katz, W G Robison
Dec 1, 1964·Experimental Eye Research·J E DOWLING
Jul 15, 1958·Proceedings of the National Academy of Sciences of the United States of America·J E Dowling, G Wald

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Citations

Jun 1, 1987·Mechanisms of Ageing and Development·M L KatzW G Robison
Sep 29, 1995·Mechanisms of Ageing and Development·M L Katz, C L Gao
Jan 1, 1989·Free Radical Biology & Medicine·G E Eldred, M L Katz
May 3, 2005·Experimental Eye Research·Janet R Sparrow, Mike Boulton
Jun 5, 2002·Mechanisms of Ageing and Development·Martin L Katz
Feb 7, 2004·Archives of Gerontology and Geriatrics·Martin L Katz, W Gerald Robison
May 30, 2009·The Journal of Biological Chemistry·Yalin WuJanet R Sparrow
May 1, 1995·The British Journal of Ophthalmology·A von RückmannA C Bird
Mar 5, 1998·The British Journal of Ophthalmology·J Wassell, M Boulton
Jul 13, 2013·Investigative Ophthalmology & Visual Science·Zsolt AblonczyRosalie K Crouch
Aug 12, 2009·Journal of Lipid Research·Janet R SparrowJilin Zhou
May 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nathan E FishkinKoji Nakanishi
Mar 11, 2008·Progress in Retinal and Eye Research·Camiel J F BoonJan E E Keunen
May 29, 2007·Progress in Retinal and Eye Research·Susanne BinderCarl Glittenberg
Feb 22, 2005·Mechanisms of Ageing and Development·Martin L KatzDouglas N Sanders
Aug 19, 2015·Micron : the International Research and Review Journal for Microscopy·Tapas Chandra Nag
May 1, 2007·Expert Opinion on Therapeutic Targets·Konstantin Petrukhin
Mar 24, 2015·Biomedical Optics Express·Sicong HeJianan Y Qu
Nov 13, 2003·Vision Research·Janet R SparrowKoji Nakanishi
Jan 3, 2012·Progress in Retinal and Eye Research·Janet R SparrowJilin Zhou
Jun 13, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Padmini DahanayakeVajira S Weerasinghe
Jan 5, 2002·The Journal of Biological Chemistry·Shimon Ben-ShabatJanet R Sparrow
May 3, 2021·Journal of Cellular and Molecular Medicine·Joe M ButlerLuminita Paraoan
Feb 4, 2006·Neurobiology of Aging·Sabrina S Seehafer, David A Pearce

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