Relationship between DNA methylation and gene expression of the HOXB gene cluster in small cell lung cancers

FEBS Letters
D FlagielloB Malfoy

Abstract

The expression pattern of the HOXB gene cluster in four xenografted small-cell lung cancers was compared to the methylation of the DNA in the corresponding genomic regions. In 90% (17/19) of the studied cases, the expressed genes were in methylated regions whereas 70% (12/17) of the unexpressed genes were in unmethylated regions. This specific behavior could correspond to a particular gene expression regulation mechanism of the HOX gene network. Since some genes (HOXB2, HOXB4, HOXB7) were always inactive when unmethylated, this unexpected relationship might indicate their key function(s) in the HOX gene network.

References

Jul 30, 1992·International Journal of Cancer. Journal International Du Cancer·C CilloE Boncinelli
Jul 1, 1991·Molecular and Cellular Biology·R BuettnerM A Tainsky
Apr 11, 1991·Nucleic Acids Research·T OguraK K Kidd
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M ArielH Cedar
Dec 25, 1989·Nucleic Acids Research·D AcamporaE Boncinelli
Jan 1, 1986·Annual Review of Genetics·W J Gehring, Y Hiromi
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·D LohnesP Chambon
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·T Ogura, R M Evans
Mar 3, 1995·The Journal of Biological Chemistry·I Vieille-Grosjean, P Huber
Jan 1, 1994·Genetica·E BoncinelliG Lavorgna
Jul 29, 1994·Cell·R Krumlauf
Aug 15, 1994·International Journal of Cancer. Journal International Du Cancer·C TiberioC Cillo
Jan 1, 1994·Progress in Nucleic Acid Research and Molecular Biology·A Razin, T Kafri
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G De VitaC Cillo
Jan 1, 1993·EXS·C H SpruckP A Jones
Jan 1, 1993·EXS·A Yeivin, A Razin

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Citations

Sep 25, 1998·Journal of the National Cancer Institute·L MiccoliS Oudard
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R LópezM Salcedo
May 6, 2010·BMC Bioinformatics·Hailong MengEdwin J C G van den Oord
May 24, 2011·Molecular Cancer·Masanao TabuseMasahiro Toda
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·H NaoraR B Roden
Dec 3, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·S Schneider-MaunouryP Charnay
May 6, 1998·Current Opinion in Neurobiology·S Pfaff, C Kintner
Jun 6, 2015·Cancer Investigation·David L TaitM Taghi Mostafavi
Jun 24, 1998·Journal of Molecular Biology·J FlynnN Reich
Aug 3, 2002·Oncogene·Jeffrey A TsouIte A Laird-Offringa

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