PMID: 2505071Sep 1, 1989Paper

Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes

Mutation Research
F MajoneF Bordin

Abstract

We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions an increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.

References

Dec 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·P J PriceR J Huebner
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R Jaenisch
May 1, 1980·Mutation Research·R B Painter

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