Relationship between dopamine release in nucleus accumbens and place preference induced by substance P injected into the nucleus basalis magnocellularis region

Neuroscience
F BoixR K Schwarting

Abstract

The activity of the neurotransmitter dopamine in the nucleus accumbens is considered to be an important element in the central processing of reinforcement. Unilateral administration of the neurokinin substance P into the area of the nucleus basalis magnocellularis of rats was found to be reinforcing, as assessed by the conditioned place preference paradigm. Simultaneous in vivo microdialysis showed that administration of substance P into the area of the nucleus basalis magnocellularis could increase extracellular concentrations of dopamine in the contralateral nucleus accumbens. Only those animals in which the administration of substance P induced this increase in dopamine levels acquired place preference. Furthermore, the changes in extracellular dopamine levels after substance P administration had a bimodal time course with an acute increase (to about 160% of baseline) during the first hour after injection, with a low (to 120-130%) and enduring increase occurring thereafter. Interestingly, during this second increase there were indications for positive correlations with the degree of place preference induced by substance P. Further positive correlations with place preference were found in the levels of the serotonergic metabo...Continue Reading

References

May 27, 1992·European Journal of Pharmacology·F BoixR K Schwarting
Jan 1, 1991·Psychopharmacology·L M Colle, R A Wise
Jan 1, 1991·Annual Review of Neuroscience·S Nakanishi
Nov 15, 1988·The Journal of Comparative Neurology·E A Grove
Nov 1, 1989·Journal of Neuroscience Methods·R U HasenöhrlJ P Huston
Mar 1, 1986·Brain Research·E Garcia-Rill
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Nov 4, 1988·Science·G F Koob, F E Bloom
Jan 1, 1988·Annals of the New York Academy of Sciences·H C Fibiger, A G Phillips
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Oct 1, 1985·Neuroscience·O T Phillipson, A C Griffiths

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Citations

Oct 6, 2000·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·E N Sokolov, W Boucsein
Nov 1, 2008·Neuroscience and Behavioral Physiology·S Yu BudilinA S Bazyan
May 27, 1992·European Journal of Pharmacology·F BoixR K Schwarting
Jan 23, 1995·Behavioural Brain Research·J P Huston, R U Hasenöhrl
Mar 1, 1997·Behavioural Brain Research·B Givens, M Sarter
Sep 22, 2000·Peptides·R CiccocioppoM Massi
Jul 29, 1998·Neuroscience·C M ThielR K Schwarting
Jun 27, 2009·Behavioural Brain Research·Erika KertesLászló Lénárd
Sep 27, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M A de Souza SilvaJ P Huston
Aug 30, 2005·Neuroscience Letters·Franca M PlacenzaSuzanne Erb
Oct 24, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Raquel C R MartinezErich Talamoni Fonoff
Jun 18, 2002·Acta Biologica Hungarica·L Lénárd, Erika Kertes
Jan 2, 2007·Brain Research·Kazuki OtaMitsuo Iida

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