Relationship Between Dry Retinal Volume and Visual Acuity in Diabetic Macular Edema

Ophthalmic Surgery, Lasers & Imaging Retina
Muneeswar Gupta NittalaSriniVas R Sadda

Abstract

To evaluate the relationship between a novel spectral-domain optical coherence tomography (SD-OCT) parameter, predicted dry retinal volume (DRV), and visual acuity (VA) in subjects with diabetic macular edema. Twenty-eight eyes of 26 subjects with macular edema secondary to diabetic retinopathy (cases) and 10 healthy eyes of normal volunteers (controls) were included. Spectral-domain optical coherence tomography volume scans (512 × 128) were obtained before and 6 months to 12 months after anti-vascular endothelial growth factor therapy. The borders of the neurosensory retina, nerve fiber layer (NFL), and vitreous were manually defined using previously described grading software. NFL reflectivity was used to normalize the signal between eyes, allowing a normalized total retinal intensity to be computed for each eye by summing the brightness of every pixel in the retina on all B-scans. Using this normalized retinal intensity, a ratio of retinal intensity of cases over retinal intensity of normal was generated. The predicted DRV was computed by multiplying this calculated ratio with total retinal volume at baseline for each eye. Correlation analysis was performed between DRV at baseline and VA at baseline and final follow-up. The ...Continue Reading

References

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Feb 4, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J Fernando ArevaloUNKNOWN Pan-American Collaborative Retina Study Group (PACORES)
Jun 12, 2010·Investigative Ophthalmology & Visual Science·Lucia PelosiniJohn Marshall
Sep 16, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Gábor Márk SomfaiDelia Cabrera Debuc
Nov 28, 2013·Ophthalmic Surgery, Lasers & Imaging Retina·Zhihong HuSriniVas R Sadda
Feb 19, 2015·The New England Journal of Medicine·UNKNOWN Diabetic Retinopathy Clinical Research NetworkRoy W Beck
Aug 5, 2016·Indian Journal of Ophthalmology·Swetha B VelagaJay Kumar Chhablani

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