Relationship between economic insecurity, inflammation, monocyte activation and intestinal integrity in children living with HIV in Uganda

AIDS Care
Sahera Dirajlal-FargoGrace A McComsey

Abstract

We aimed to evaluate differences in socio-economic variables in a Ugandan cohort of children with perinatally acquired HIV (PHIVs), HIV exposed uninfected (HEU) and HIV unexposed uninfected (HIV-) children and their associations with markers of inflammation and intestinal integrity. This is a cross-sectional study in 57 PHIV, 59 HEU and 56 HIV - children aged 2-10 years old enrolled in Uganda. Mean age of all participants was 7 years and 55% were girls. Compared to HEU and HIV - children, PHIVs were more likely to have parents that only completed a primary education, live in a household without electricity and live in poverty (p≤0.034). PHIVs living in poverty had higher IL-6 (p=0.006), those with lack of electricity had higher hsCRP, IL6, sTNFRII and d-dimer (p≤0.048) and PHIVs with an unprotected water source had higher IL6 and d-dimer (p≤0.016). After adjusting for demographic and HIV variables, IL-6 and d-dimer remained associated with lack of electricity and having an unprotected water source only in PHIVs (p<0.019). Our findings suggest that addressing economic insecurity may mitigate the persistent low-level inflammation in HIV that lead to many end organ disease. Longitudinal studies are needed to better understand the ...Continue Reading

References

Oct 26, 2007·PLoS Medicine·Peter PiotSarah Russell
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Nov 18, 2011·The American Journal of Clinical Nutrition·Sheri D WeiserDavid R Bangsberg
May 30, 2014·Journal of the American Heart Association·Anna D NordellUNKNOWN SILCAAT Scientific Committee
May 18, 2016·The Journal of Infectious Diseases·Andrew J PrendergastUNKNOWN ARROW Trial Team
Jun 28, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nikolas I WadaLisa P Jacobson
Jan 10, 2017·The Pediatric Infectious Disease Journal·Sahera Dirajlal-FargoGrace A McComsey
Mar 23, 2017·The Journal of Infectious Diseases·Sulggi LeePeter W Hunt

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