Relationship between energy expenditure, physical activity and weight loss during CPAP treatment in obese OSA subjects

Respiratory Medicine
Michele BambergaFrancesco Fanfulla

Abstract

Increased energy expenditure (EE) has been reported in patients with obstructive sleep apnea (OSA). It has been postulated that CPAP treatment may induce weight reduction in obese patients, even if it has not been confirmed by recent studies. In the present study we investigated the effect of OSA on EE and the effect of CPAP on body weight and physical activity. One hundred and seven obese OSA patients and 25 healthy obese volunteers, as control group, matched for age, sex and BMI, were enrolled. The following evaluation was performed only in OSA patients after 6 months of CPAP treatment. Baseline total EE was similar in the two groups, but OSA patients showed higher EE during the night, while control group during daytime. In patients, EE correlates with OSA severity, degree of daytime sleepiness or obesity. At follow-up evaluation, BMI and total EE were unchanged. However, daytime EE increased (1066 ± 131.5 vs 1104 ± 133 Kcal/die, p < 0.001, respectively) and night EE decreased (694 ± 69 vs 595 ± 73, p < 0.0001, respectively). Statistically significant changes in BMI, sleepiness scale, blood gases and EE were found only in patients who were compliant to CPAP. Obese OSA patients showed an increased night EE that was normalized ...Continue Reading

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Citations

Jun 22, 2016·Metabolism: Clinical and Experimental·Judith Aron-WisnewskyJean-Louis Pépin
Jul 3, 2016·International Journal of Pediatric Otorhinolaryngology·Ida Gillberg AndersenPreben Homøe
Mar 2, 2016·American Journal of Respiratory and Critical Care Medicine·Ryo TachikawaKazuo Chin
May 21, 2016·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Irene TaglienteSergio Bella
May 5, 2018·Acta Clinica Belgica·Evelien Van OffenwertDries Testelmans
Mar 19, 2020·Journal of Obesity·Claire B CumminsOscar E Suman
Jul 20, 2018·Sleep & Breathing = Schlaf & Atmung·Trent A HargensChristopher J Womack
Sep 4, 2020·International Journal of Environmental Research and Public Health·Antonio Jurado-GarcíaBernabé Jurado-Gamez
Mar 2, 2021·European Clinical Respiratory Journal·Miia M AroTarja Saaresranta
Jul 21, 2021·Scientific Reports·Antonio Martinez-NicolasMaría Angeles Rol

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