Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research : CR
Long YanChao-Liu Dai

Abstract

Epithelial-to-mesenchymal transition (EMT) is a complex process involving multiple genes, steps and stages. It refers to the disruption of tight intercellular junctions among epithelial cells under specific conditions, resulting in loss of the original polarity, order and consistency of the cells. Following EMT, the cells show interstitial cell characteristics with the capacity for adhesion and migration, while apoptosis is inhibited. This process is critically involved in embryogenesis, wound-healing, tumor invasion and metastasis. The tumor microenvironment is composed of infiltrating inflammatory cells, stromal cells and the active medium secreted by interstitial cells. Most patients with hepatocellular carcinoma (HCC) have a history of hepatitis virus infection. In such cases, major components of the tumor microenvironment include inflammatory cells, inflammatory factors and virus-encoded protein are major components. Here, we review the relationship between EMT and the inflammatory tumor microenvironment in the context of HCC. We also further elaborate the significant influence of infiltrating inflammatory cells and inflammatory mediators as well as the products expressed by the infecting virus in the tumor microenvironmen...Continue Reading

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Citations

Jul 5, 2019·Journal of Cellular Biochemistry·Ganxun LiZeyang Ding
Mar 19, 2020·Journal of Experimental & Clinical Cancer Research : CR·Lidia ChelliniMaria Paola Paronetto
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Wenjian ChenJun Sun
Mar 14, 2019·International Journal of Molecular Medicine·Chenmin SunMin Liu
Jan 15, 2020·Journal of Experimental & Clinical Cancer Research : CR·Chi ShuBo Zhu
Jan 6, 2021·Journal of Cellular Physiology·Qi YanJian Du
Aug 17, 2019·Cellular Signalling·Si-Nan SunTao Xu
Mar 9, 2021·Frontiers in Molecular Biosciences·Wenjian ChenJinian Wang
Nov 6, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Qingfang ZengWei Zhou
May 14, 2021·Frontiers in Pharmacology·Fei XuWenqiang Cui
May 19, 2021·Archives of Toxicology·Javier De Las RivasAngélica Figueroa
Aug 28, 2021·Hormone Molecular Biology and Clinical Investigation·Candace MietheRamona S Price

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Methods Mentioned

BETA
xenograft
ubiquitination
transgenic
gene modification

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