Relationship between exhaled nitric oxide levels and compliance with inhaled corticosteroids in asthmatic children

Respiratory Medicine
Maria KatsaraMark L Everard

Abstract

Levels of exhaled nitric oxide (eNO) are elevated in subjects with asthma and fall in response to oral or inhaled steroids. This study explored the possibility the measurement of eNO levels could be used to identify subjects who were not adhering to their treatment regimen. Twenty children with asthma attending the respiratory clinic were recruited. Each attended on four occasions 1 month apart when eNO levels were measured. A data logger attached to a pressurised metered dose inhaler was used to objectively monitor use of inhaled corticosteroids (ICSs). The correlation between day and dose compliance with eNO was assessed. The data demonstrated a weak but non-significant correlation between eNO and both day (r = 0.055, P = 0.67) and dose (r = 0.153, P = 0.23). A recorded value of eNO less than 12 was associated with day compliance rates of 3-97%. Of the 19 recorded eNO values greater than 12 ppb almost 80% were from subjects with a day compliance of less than 50% during the preceding month. Of the four values greater than 12 ppb and day compliance > 60% one subject had a poor inhaler technique, one had a mild viral exacerbation and one appeared to be associated with increase pollen exposure. The measurement of eNO may prove to...Continue Reading

References

Jan 1, 1990·Respiratory Medicine·C R HornG M Cochrane
May 1, 1996·The European Respiratory Journal·G L BraunsteinA E Harper
Nov 1, 1996·The European Respiratory Journal·C M BosleyG M Cochrane
Dec 1, 1996·The Journal of Allergy and Clinical Immunology·H MilgromC Rand
Oct 24, 1997·The Journal of Allergy and Clinical Immunology·C CalpinP C Parkin
Aug 13, 1999·The European Respiratory Journal·A ArtlichK J Falke
Aug 26, 1999·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·L M OsmanJ G Douglas
Dec 22, 1999·Respiratory Medicine·G M CochraneP Chanez
Jun 15, 2000·The European Respiratory Journal·G L PiacentiniA L Boner
Sep 22, 2000·Archives of Disease in Childhood·G JónassonP Mowinckel
Oct 14, 2000·The Journal of Allergy and Clinical Immunology·G S BerlyneF E Hargreave
Dec 6, 2000·The European Respiratory Journal·S A Kharitonov, P J Barnes
Dec 22, 2000·Respiration; International Review of Thoracic Diseases·I TsujinoY Kawakami
Sep 20, 2001·Thorax·T HaahtelaUNKNOWN Working Group of the Asthma Programme in Finland 1994-2004
Sep 25, 2001·Pediatric Pulmonology·A AvitalC Springer
Jul 3, 2002·Pediatrics·Laurie J BaumanCynthia M Visness
Jul 11, 2002·The European Respiratory Journal·J Beck-RippP Bufler
Jan 28, 2005·Respiratory Medicine·Victoria K BrennanMark L Everard

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Citations

Jun 30, 2009·Annals of Thoracic Medicine·Mohammed F S BegSyed S Habib
Nov 8, 2007·Current Allergy and Asthma Reports·Rohit Katial, Lora Stewart
May 8, 2008·Chest·Kaiser G Lim, Carl Mottram
Aug 11, 2012·Immunology and Allergy Clinics of North America·Lora Stewart, Rohit K Katial
Nov 13, 2007·Immunology and Allergy Clinics of North America·Lora Stewart, Rohit Katial
Dec 14, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M W H Pijnenburg, J C De Jongste
Jul 3, 2007·Orvosi hetilap·Balázs Antus, Ildikó Horváth
Oct 24, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M L Everard
Dec 1, 2007·Journal of Breath Research·Balázs Antus, Ildikó Horváth
Oct 2, 2012·American Journal of Respiratory and Critical Care Medicine·Diarmuid M McNichollLiam G Heaney
Feb 11, 2016·European Journal of Gastroenterology & Hepatology·Guy GutYakov Sivan
Nov 16, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Fahad AlahmadiStephen J Fowler

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