Relationship between exposure, body burden and target tissue concentration after oral administration of a low-dose mixture of pyrethroid insecticides in young adult rats

Toxicology
Mónica Elizabeth Mosquera OrtegaMarcelo Javier Wolansky

Abstract

Pyrethroids (PYRs) are synthetic insecticides increasingly used in agricultural and household pest control. Little is known on how the toxicity of highly effective bolus doses of single compounds compares to more realistic scenarios of low-level exposure to PYR mixtures. In this study, we examined a quaternary mixture of two noncyano (tefluthrin, TEF; bifenthrin, BIF) and two cyano (α-cypermethrin, α-CPM; deltamethrin, DTM) PYRs in young adult rats. These compounds are mostly composed of PYR isomers ranking top ten in acute lethality in rats. Concurrently, we administered near-threshold levels of the four PYRs dissolved in corn oil by oral route. Six hours later blood was collected and the liver and cerebellum were dissected out to determine PYR concentrations in these tissues using Gas Chromatography with Electron Capture Detector (GC-ECD). The mixture caused mild-to-moderate changes in non-locomotor behaviors and subcutaneous body temperature (up to +1.2-1.5 °C increase at 2-4 h after dosing, respectively, compared to pre-dosing records). The most toxic PYRs BIF and TEF reached higher concentrations in the cerebellum than the cyano-compounds α-CPM and DTM. In addition, PYR concentrations in the cerebellum were correlated to s...Continue Reading

Citations

Oct 2, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mónica Elizabeth Mosquera OrtegaMarcelo Javier Wolansky
Dec 16, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yasmina M Abd-ElhakimMostafa A Shalaby
Dec 12, 2020·Saudi Journal of Biological Sciences·Hui LiuNarendra Maddu

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