Relationship Between Fibrosis Detected on Late Gadolinium-Enhanced Cardiac Magnetic Resonance and Re-Entrant Activity Assessed With Electrocardiographic Imaging in Human Persistent Atrial Fibrillation

JACC. Clinical Electrophysiology
Hubert CochetPierre Jaïs

Abstract

This study sought to assess the relationship between fibrosis and re-entrant activity in persistent atrial fibrillation (AF). The mechanisms involved in sustaining re-entrant activity during AF are poorly understood. Forty-one patients with persistent AF (age 56 ± 12 years; 6 women) were evaluated. High-resolution electrocardiographic imaging (ECGI) was performed during AF by using a 252-chest electrode array, and phase mapping was applied to locate re-entrant activity. Sites of high re-entrant activity were defined as re-entrant regions. Late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR) was performed at 1.25 × 1.25 × 2.5 mm resolution to characterize atrial fibrosis and measure atrial volumes. The relationship between LGE burden and the number of re-entrant regions was analyzed. Local LGE density was computed and characterized at re-entrant sites. All patients underwent catheter ablation targeting re-entrant regions, the procedural endpoint being AF termination. Clinical, CMR, and ECGI predictors of acute procedural success were then analyzed. Left atrial (LA) LGE burden was 22.1 ± 5.9% of the wall, and LA volume was 74 ± 21 ml/m2. The number of re-entrant regions was 4.3 ± 1.7 per patient. LA LGE imaging was sig...Continue Reading

References

Apr 29, 1982·The New England Journal of Medicine·W B KannelP M McNamara
Oct 25, 2000·Circulation·J E BurnesY Rudy
Jun 14, 2002·Cardiovascular Research·José JalifeMoussa Mansour
Jun 14, 2002·Cardiovascular Research·Sawa KostinJutta Schaper
Mar 23, 2004·Nature Medicine·Charulatha RamanathanYoram Rudy
Oct 1, 2005·Progress in Cardiovascular Diseases·Stanley NattelLéna Rivard
Feb 8, 2006·Circulation·Michel HaïssaguerrePierre Jaïs
Dec 22, 2006·American Journal of Epidemiology·Eric Vittinghoff, Charles E McCulloch
Feb 26, 2008·Journal of the American College of Cardiology·Brett Burstein, Stanley Nattel
Jun 30, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Masatoshi YamazakiJérôme Kalifa
Jul 28, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·João AbecasisAniceto Silva
Nov 15, 2011·Journal of the American College of Cardiology·Pyotr G PlatonovSiew Yen Ho
Feb 5, 2013·Journal of Cardiovascular Electrophysiology·Michel HaissaguerreRemi Dubois
Jun 26, 2013·Biophysical Journal·Kathleen S McDowellNatalia A Trayanova
Dec 24, 2013·Circulation. Arrhythmia and Electrophysiology·Christopher McGannNassir F Marrouche
Feb 6, 2014·JAMA : the Journal of the American Medical Association·Nassir F MarroucheJohannes Brachmann
Jul 17, 2014·Circulation·Michel HaissaguerreRemi Dubois
Nov 2, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Matthew J GonzalesAndrew D McCulloch
Nov 17, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jonathan ChrispinSaman Nazarian
Sep 1, 2012·Cardiac Electrophysiology Clinics·Ashok J ShahPierre Jais
Dec 3, 2016·Circulation. Arrhythmia and Electrophysiology·Ramya VijayakumarYoram Rudy

❮ Previous
Next ❯

Citations

Jul 13, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Tarek Zghaib, Saman Nazarian
Aug 21, 2019·Nature Biomedical Engineering·Patrick M BoyleNatalia A Trayanova
Oct 5, 2019·Cardiology in Review·Mina K ChungJohn Barnard
Nov 22, 2019·The International Journal of Cardiovascular Imaging·Litten BertelsenJesper Hastrup Svendsen
Mar 29, 2019·Arrhythmia & Electrophysiology Review·Stylianos TzeisPanos Vardas
Oct 3, 2020·Journal of the American Heart Association·Brian J HansenVadim V Fedorov
Sep 26, 2019·Frontiers in Physiology·Jason D BayerJoris R de Groot
Jul 21, 2020·Arrhythmia & Electrophysiology Review·Caroline H RoneyNicholas S Peters
Nov 27, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Caroline H RoneySteven A Niederer
Dec 6, 2018·Current Opinion in Cardiology·Yenn-Jiang LinShih-Ann Chen
Oct 10, 2018·Frontiers in Physiology·Martino AlessandriniStefano Severi
Sep 25, 2018·Frontiers in Physiology·Mirabeau SahaEdward J Vigmond
Nov 13, 2019·European Heart Journal·Christian Sohns, Nassir F Marrouche
Jan 23, 2020·Physical Review. E·Max FalkenbergKim Christensen
Nov 22, 2018·Frontiers in Physiology·Ghassen ChenitiFrederic Sacher
Feb 26, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Clemens Jilek, Waqas Ullah
Nov 27, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Joe B HakimPatrick M Boyle
Dec 7, 2020·European Journal of Human Genetics : EJHG·Julie H AndersenMorten S Olesen
Jan 10, 2021·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Gian-Battista ChierchiaCarlo de Asmundis
Nov 11, 2019·Cardiac Electrophysiology Clinics·Dennis H LauPrashanthan Sanders
Feb 19, 2021·Journal of Cardiovascular Electrophysiology·Nassir F MarroucheUNKNOWN DECAAF II Investigators
Oct 15, 2020·Nature Reviews. Cardiology·Ramanathan ParameswaranJonathan M Kalman
May 27, 2020·Cardiac Electrophysiology Clinics·Mohammadali HabibiHugh Calkins
Mar 9, 2021·Journal of Cardiovascular Electrophysiology·Jing X QuahAnand Ganesan
Feb 14, 2019·International Journal of Cardiology·Konstantinos N AronisNatalia A Trayanova
Jun 15, 2021·Frontiers in Physiology·Marica MuffolettoOleg Aslanidi
May 17, 2021·Journal of Cardiovascular Electrophysiology·Jayson R BamanJane E Wilcox
Aug 27, 2021·Frontiers in Cardiovascular Medicine·Yuye NingGuoliang Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.