Relationship between five GWAS-identified single nucleotide polymorphisms and female breast cancer in the Chinese Han population

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yaning HeYingbo Shao

Abstract

With the development of genome-wide association study (GWAS), an increasing number of genetic variables have been confirmed to be associated with breast cancer. Furthermore, an increasing number of studies from Asian populations are becoming available. Few GWAS loci have been replicated in the Chinese Han population. In a case-control study of breast cancer in the Henan Tumor Hospital (253 cases/339 controls), we evaluated five SNPs from GWAS of populations of European or Asian ancestry. In order to evaluate the contribution of genetic factors to population differences in breast cancer subtypes, all cases are defined by estrogen (ER), progesterone (PR) receptor, Human epidermal growth factor receptor - 2 (HER2), and Ki67 status. Different genotypes of rs3803662 (TOX3)/ (TNRC9)) in the case group and the control group are statistically significant (P = 0.044), but the ones of rs10069690 (TERT), rs2046210 (6q25.1), rs2981582 (EGFR2), and rs889312 (MAP3K1) have no significant statistical differences with breast cancer (P = 0.772, 0.308, 0.376, 0.468). The allelic frequencies of rs3803662 between the case group and the control group differ in recessive genetic models (odds ratio (OR) = 2.04, 95 % confidence interval (CI) 1.14-3.66)...Continue Reading

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Citations

Aug 31, 2016·Breast Cancer Research and Treatment·Minggui XuBo Zhang
Jul 19, 2019·Molecular Genetics & Genomic Medicine·Yaning HeSuxia Luo
Aug 28, 2019·Journal of Clinical Laboratory Analysis·Wendong HuangXiaoqiong Gu

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