Relationship Between Foveal Cone Structure and Visual Acuity Measured With Adaptive Optics Scanning Laser Ophthalmoscopy in Retinal Degeneration.

Investigative Ophthalmology & Visual Science
Katharina G FooteJacque L Duncan

Abstract

To evaluate foveal function in patients with inherited retinal degenerations (IRD) by measuring visual acuity (VA) after correction of higher-order aberrations. Adaptive optics scanning laser ophthalmoscopy (AOSLO) was used to image cones in 4 healthy subjects and 15 patients with IRD. The 840-nm scanning laser delivered an "E" optotype to measure AOSLO-mediated VA (AOSLO-VA). Cone spacing was measured at the preferred retinal locus by two independent graders and the percentage of cones below the average density of 47 age-similar healthy subjects was computed. Cone spacing was correlated with best-corrected VA measured with the Early Treatment of Diabetic Retinopathy Study protocol (ETDRS-VA), AOSLO-VA, and foveal sensitivity. ETDRS-VA significantly correlated with AOSLO-VA (ρ = 0.79, 95% confidence interval [CI] 0.5-0.9). Cone spacing correlated with AOSLO-VA (ρ = 0.54, 95% CI 0.02-0.7), and negatively correlated with ETDRS letters read (ρ = -0.64, 95% CI -0.8 to -0.2). AOSLO-VA remained ≥20/20 until cones decreased to 40.2% (CI 31.1-45.5) below normal. Similarly, ETDRS-VA remained ≥20/20 until cones were 42.0% (95% CI 36.5-46.1) below normal. Cone spacing z scores negatively correlated with foveal sensitivity (ρ = -0.79, 95% ...Continue Reading

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Citations

Mar 30, 2019·Investigative Ophthalmology & Visual Science·Katharina G FooteJacque L Duncan
Jul 25, 2019·Investigative Ophthalmology & Visual Science·Ethan BensingerJacque L Duncan
Apr 29, 2020·Investigative Ophthalmology & Visual Science·Katharina G FooteJacque L Duncan
Dec 20, 2019·Biomedical Optics Express·Min ChenJessica I W Morgan
Aug 25, 2020·Translational Vision Science & Technology·Debra A ThompsonUNKNOWN Monaciano Consortium
Nov 27, 2019·Investigative Ophthalmology & Visual Science·Katharina G FooteJacque L Duncan
Sep 1, 2020·Survey of Ophthalmology·Xing D Chen, Thomas W Gardner
Jun 11, 2021·Translational Vision Science & Technology·Katie M LittsJoseph Carroll
Jul 22, 2021·Investigative Ophthalmology & Visual Science·Niklas DomdeiWolf M Harmening
Sep 16, 2021·Annual Review of Vision Science·Joo Yeun LeeFelice A Dunn
Sep 23, 2021·Investigative Ophthalmology & Visual Science·Ellen Townes-AndersonMarco Zarbin

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Methods Mentioned

BETA
Scanning Laser Ophthalmoscopy

Software Mentioned

eyeGENE
VA
MATLAB
AOSLO

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