PMID: 2507700Jan 1, 1989Paper

Relationship between free radicals and vitamins: an overview

International Journal for Vitamin and Nutrition Research. Supplement = Internationale Zeitschrift Für Vitamin- Und Ernährungsforschung. Supplement
H Sies

Abstract

Aerobic metabolism entails the generation of reactive oxygen species. These include the superoxide anion radical, hydrogen peroxide, the hydroxyl radical, and singlet molecular oxygen. Further, organic alkoxyl or peroxyl radicals may be formed. In the pattern of antioxidant defense, some vitamins play a prominent role and have therefore received much attention recently in the study of the physiological or pathophysiological imbalance in the prooxidant/antioxidant equilibrium. Prooxidant states are sometimes also referred to as oxidative stress. Vitamin E in the membrane compartment and vitamin C in the aqueous compartment exhibit direct reactivity with radicals, and there are repair pathways for the tocopheryl and ascorbyl radicals that are generated. In this regard, there can be an interaction between these two vitamins. Also, glutathione (GSH) can exhibit repair capacity as well as direct reactivity with radicals. Singlet molecular oxygen is an electronically excited state of oxygen with considerable chemical reactivity. It is a non-radical compound, generated by photochemical reactions or by the process of lipid peroxidation of biomembranes, i.e., by photoexcitation or by chemiexcitation. Singlet oxygen can be inactivated by...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
T Fujita, Y Fujimoto
Chemical Research in Toxicology
Adriana C VelosaEtelvino J H Bechara
Journal of Photochemistry and Photobiology. B, Biology
R M Tyrrell, S M Keyse
Free Radical Biology & Medicine
L PackerH J Tritschler
© 2022 Meta ULC. All rights reserved