Relationship between functional residual capacity and oxygen desaturation during short central apneic events during sleep in "late preterm" infants

Pediatric Research
Pierre TourneuxVéronique Bach

Abstract

Apneic episodes are frequent in the preterm neonate and particularly in active sleep (AS), when functional residual capacity (FRC) can be decreased. Furthermore, FRC may be inversely correlated with the speed of blood-O(2)-desaturation. We evaluated the potential involvement of FRC in the mechanisms responsible for blood-O(2)-desaturation during short central apneic events (>3 s) in "late-preterm" infants and analyzed the specific influence of sleep state. Apneic events were scored in 29 neonates (postmenstrual age: 36.1 +/- 1.2 wk) during AS and quiet sleep (QS). FRC was measured during well-established periods of regular breathing. Apneas with blood-O(2)-desaturation (drop in SpO(2) >5% from the baseline, lowest SpO(2) during apnea: 91.4 +/- 1.8%) were more frequent in AS than in QS, whereas no difference was seen for apneas without desaturation. The magnitude of the FRC did not depend on the sleep state. In AS only, there was a negative relationship between FRC and the proportion of apneas with desaturation. Even in late preterm infants who do not experience long-lasting apnea, blood-O(2)-desaturation during short apneic events is related (in AS but not QS) to a low baseline FRC. Sleep stage differences argue for a major rol...Continue Reading

References

Jun 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D J Henderson-Smart, D J Read
Feb 1, 1979·The Journal of Pediatrics·R J MartinD Rubin
Jul 1, 1990·Diagnostic Microbiology and Infectious Disease·M T WilsonT R Mervak
Jan 1, 1989·European Journal of Pediatrics·G M StokesA J Wilson
Jan 1, 1989·Pediatric Pulmonology·C S BeardsmoreH Simpson
Nov 1, 1966·Journal of Applied Physiology·N S CherniackA P Fishman
Jan 1, 1983·Biology of the Neonate·L Curzi-Dascalova, E Christova-Guéorguiéva
Jan 1, 1983·Biology of the Neonate·G MorietteJ P Relier
Aug 1, 1982·Critical Care Medicine·R R MitchellJ J Osborn
Mar 1, 1981·The Journal of Pediatrics·T A Marshall, J Kattwinkel
Oct 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J LopesA C Bryan
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·C F PoetsJ Seidenberg
Oct 6, 1997·The European Respiratory Journal·C J NewthR L Johnson
Nov 28, 1997·Medical & Biological Engineering & Computing·F TelliezJ P Libert
Oct 6, 1997·Pediatric Research·J A AdamsM A Sackner
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·B BouferracheC Gaultier
Dec 31, 2002·Sleep Medicine Reviews·Veronique BachJean Pierre Libert
Oct 2, 2003·Neurophysiologie clinique = Clinical neurophysiology·K ChardonJ P Libert
Nov 30, 2004·Seminars in Perinatology·Abdulrahman Al-MataryHenrique Rigatto
Jun 7, 2005·European Journal of Pediatrics·Anne GreenoughJaana A Leipälä
Jun 30, 2005·Biology of the Neonate·Richard J Martin, Jalal M Abu-Shaweesh
Jul 13, 2006·Journal of Clinical Monitoring and Computing·Dieter WeismannJochen Schulte
Dec 7, 2006·Clinics in Perinatology·Robert A DarnallHannah C Kinney

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Citations

Dec 10, 2009·PLoS Computational Biology·Scott A SandsPhilip J Berger
Dec 14, 2011·European Journal of Applied Physiology·Pauline DécimaJean-Pierre Libert
Feb 22, 2016·Journal of Clinical Monitoring and Computing·Omid Sadeghi FathabadiPeter A Dargaville
Aug 21, 2012·Respiratory Physiology & Neurobiology·Estelle B GaudaRaul Chavez-Valdez
Jun 19, 2012·Respiratory Physiology & Neurobiology·Bradley A EdwardsPhilip J Berger
Jul 21, 2009·Respiratory Physiology & Neurobiology·Bradley A EdwardsPhilip J Berger
Feb 27, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Ferdinand CosteJames Kemp
Apr 18, 2015·BMC Pediatrics·Gloria S PryhuberUNKNOWN Prematurity and Respiratory Outcomes Program Investigators
Aug 9, 2018·Annals of the American Thoracic Society·Clement L RenJames S Kemp
Oct 31, 2021·Pediatric Research·Leon S SiriwardhanaRosemary S C Horne

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