Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila.

Cell Death and Differentiation
Donna DentonSharad Kumar

Abstract

Autophagy has been implicated in both cell survival and programmed cell death (PCD), and this may explain the apparently complex role of this catabolic process in tumourigenesis. Our previous studies have shown that caspases have little influence on Drosophila larval midgut PCD, whereas inhibition of autophagy severely delays midgut removal. To assess upstream signals that regulate autophagy and larval midgut degradation, we have examined the requirement of growth signalling pathways. Inhibition of the class I phosphoinositide-3-kinase (PI3K) pathway prevents midgut growth, whereas ectopic PI3K and Ras signalling results in larger cells with decreased autophagy and delayed midgut degradation. Furthermore, premature induction of autophagy is sufficient to induce early midgut degradation. These data indicate that autophagy and the growth regulatory pathways have an important relationship during midgut PCD. Despite the roles of autophagy in both survival and death, our findings suggest that autophagy induction occurs in response to similar signals in both scenarios.

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Citations

Jul 23, 2013·Nature Cell Biology·Tsun-Kai ChangEric H Baehrecke
Sep 23, 2014·Cell Death and Differentiation·L GalluzziG Kroemer
Dec 18, 2013·Nature Communications·Donna DentonSharad Kumar
Oct 18, 2014·The FEBS Journal·Charles Nelson, Eric H Baehrecke
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Apr 18, 2015·Cell Death and Differentiation·T XuS Kumar
Aug 22, 2014·BioMed Research International·Davide RomanelliGianluca Tettamanti
Mar 15, 2013·Autophagy·Jun-Lin GuanJue Zhang
Jul 3, 2013·Biochimica Et Biophysica Acta·Donna DentonSharad Kumar
Oct 22, 2014·Immunology and Cell Biology·Donna DentonSharad Kumar
Jul 16, 2016·Insect Biochemistry and Molecular Biology·Matthew W EngDavid W Severson
Jan 25, 2018·Cell Death and Differentiation·Lorenzo GalluzziGuido Kroemer
Feb 9, 2019·PloS One·Marc BourouisPierre Leopold
Feb 26, 2015·The EMBO Journal·Lorenzo GalluzziGuido Kroemer
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Jul 1, 2018·Cell Death and Differentiation·Donna DentonSharad Kumar
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Nov 21, 2019·Cell Death and Differentiation·Tianqi XuSharad Kumar
Oct 27, 2018·Journal of Developmental Biology·Alla YalonetskayaKimberly McCall
Feb 10, 2019·Cell Death & Disease·Donna DentonSharad Kumar
Dec 21, 2018·Cell Death and Differentiation·Donna Denton, Sharad Kumar
Dec 29, 2020·Frontiers in Cellular and Infection Microbiology·Shirley Luckhart, Michael A Riehle
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Lawrence M Schwartz
Jul 27, 2021·The EMBO Journal·Rojyar KhezriTor Erik Rusten

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